Table 1. Summary of Ca 2 sensitivities... | Rockefeller University Press

Table 1.

Summary of Ca²⁺ sensitivities of the ANO2 isoforms

	−40 mV						+40 mV
Values derived from I_max	Isoform A	Isoforms A + A_Δ4	Isoform B	Isoforms B + B_Δ4	Native channel (mouse)	ANO2 variant Stephan et al., 2009	Isoform A	Isoforms A + A_Δ4	Isoform B	Isoforms B + B_Δ4	Native channel (mouse)	ANO2 variant Stephan et al., 2009
K_1/2 (µM)	2.1 ± 0.26	1.65 ± 0.13	1.33 ± 0.13	2.04 ± 0.20	3.46 ± 0.21	1.83 ± 0.03	1.35 ± 0.11	0.96 ± 0.09	1.08 ± 0.07	1.45 ± 0.19	1.48 ± 0.08	1.18 ± 0.11
n Hill Coeff.	1.79 ± 0.38	1.91 ± 0.23	2.49 ± 0.39	2.61 ± 0.81	1.41 ± 0.1	2.3 ± 0.07	1.87 ± 0.23	2.32 ± 0.47	2.13 ± 0.25	2.99 ± 0.65	3.12 ± 0.27	1.92 ± 0.27
I_10s/I_max at 67 µM Ca²⁺	0.62 ± 0.06	0.4 ± 0.05	0.55 ± 0.07	0.43 ± 0.07	0.59 ± 0.05	0.41 ± 0.06	1.05 ± 0.08	1 ± 0.07	0.97 ± 0.06	0.79 ± 0.07	0.50 ± 0.06	0.98 ± 0.04

	−40 mV						+40 mV
Values derived from I_max	Isoform A	Isoforms A + A_Δ4	Isoform B	Isoforms B + B_Δ4	Native channel (mouse)	ANO2 variant Stephan et al., 2009	Isoform A	Isoforms A + A_Δ4	Isoform B	Isoforms B + B_Δ4	Native channel (mouse)	ANO2 variant Stephan et al., 2009
K_1/2 (µM)	2.1 ± 0.26	1.65 ± 0.13	1.33 ± 0.13	2.04 ± 0.20	3.46 ± 0.21	1.83 ± 0.03	1.35 ± 0.11	0.96 ± 0.09	1.08 ± 0.07	1.45 ± 0.19	1.48 ± 0.08	1.18 ± 0.11
n Hill Coeff.	1.79 ± 0.38	1.91 ± 0.23	2.49 ± 0.39	2.61 ± 0.81	1.41 ± 0.1	2.3 ± 0.07	1.87 ± 0.23	2.32 ± 0.47	2.13 ± 0.25	2.99 ± 0.65	3.12 ± 0.27	1.92 ± 0.27
I_10s/I_max at 67 µM Ca²⁺	0.62 ± 0.06	0.4 ± 0.05	0.55 ± 0.07	0.43 ± 0.07	0.59 ± 0.05	0.41 ± 0.06	1.05 ± 0.08	1 ± 0.07	0.97 ± 0.06	0.79 ± 0.07	0.50 ± 0.06	0.98 ± 0.04

All values are mean ± SEM (6–11 patches). Mouse-native channel values are from Reisert et al., 2005, and Table S2 in Stephan et al., 2009.