Table 1.
Patients suffering from MMR vaccine-related disease
Gene mutatedAge (mo) at first MMR vaccinationAge (yr) at last known follow-upClinical manifestations
STAT2 P1 (Hambleton et al., 2013) 18 5 P1: 6 d following MMR vaccination, the patient developed fever, rash, conjunctivitis, and lymphadenopathy, followed by hepatitis and pneumonitis requiring supplemental oxygen. Patient recovered from MMR infection. 
STAT2 P2, P3 (Shahni et al., 2015) 12, 13 3, 2.5 P2: 1 wk after MMR vaccination, the patient developed a febrile illness. Readmitted 1 mo later with opsoclonus-myoclonus and lymphocytes in the CSF, readmitted again at 2.5 yr with impaired renal and liver function, opsoclonus-myoclonus, and seizures. Patient recovered from MMR infection. 
P3: 1 wk after MMR vaccination, the patient developed a febrile illness, anemia, and lymphopenia. CSF was positive for mumps virus by PCR. Readmitted at 15 mo due to persistent fever and malaise, eventually developed septic shock and metabolic acidosis. Patient recovered from MMR infection. 
STAT2 P4, P5 (Moens et al., 2017) 24, 18 7a, 11 P4: 1 wk after MMR vaccination, the patient developed a morbilliform rash, tonsillitis, conjunctivitis, lymphadenopathy, hepatosplenomegaly, and arthritis. Patient recovered from MMR infection. Patient experienced frequent severe viral infections during the first 3 yr and died at 7 yr of fulminant viral infection. 
P5: 1 wk after MMR vaccination, the patient developed disseminated measles, complicated by hepatitis and pneumonitis. Patient recovered from MMR infection. 
IFNAR2 (Duncan et al., 2015) 13 1.3a 6 d after MMR vaccination, the patient developed a marked injection-site reaction and generalized morbilliform skin rash, recurrent maculopapular rash, fever, and intractable seizures. Patient died on day 81 after vaccination. 
IRF7 (Ciancanelli et al., 2015) 12 9 1 wk after MMR vaccination, the patient developed a rash suggestive of measles. Patient recovered from MMR infection. Patient also suffered from a life-threatening influenza infection at 3 yr of age. 
IRF9 (Hernandez et al., 2018) 16 5 2 wk after MMR vaccination, the patient developed an idiopathic biliary perforation. Patient recovered from MMR infection. Patient also suffered a life-threatening influenza infection at 2 yr of age, parainfluenza virus at age 4, and recurrent fevers without a causative pathogen identified throughout her childhood. 
STAT1 (Burns et al., 2016) 13 2 1 wk after MMR vaccination, patient developed fever, irritability, rash, diarrhea, encephalitis, a hemophagocytic lymphohistiocytosis-like syndrome, and was positive for human herpesvirus 6. Patient was readmitted 7 d later with refusal to walk, unsteady gait, and inflammatory cells in the CSF. Patient recovered from MMR infection. 
IFNAR1 P1 (this report) 12 9 10 d after MMR vaccination, patient developed a generalized exanthema, fever, and encephalitis. Patient recovered from MMR infection. 
Gene mutatedAge (mo) at first MMR vaccinationAge (yr) at last known follow-upClinical manifestations
STAT2 P1 (Hambleton et al., 2013) 18 5 P1: 6 d following MMR vaccination, the patient developed fever, rash, conjunctivitis, and lymphadenopathy, followed by hepatitis and pneumonitis requiring supplemental oxygen. Patient recovered from MMR infection. 
STAT2 P2, P3 (Shahni et al., 2015) 12, 13 3, 2.5 P2: 1 wk after MMR vaccination, the patient developed a febrile illness. Readmitted 1 mo later with opsoclonus-myoclonus and lymphocytes in the CSF, readmitted again at 2.5 yr with impaired renal and liver function, opsoclonus-myoclonus, and seizures. Patient recovered from MMR infection. 
P3: 1 wk after MMR vaccination, the patient developed a febrile illness, anemia, and lymphopenia. CSF was positive for mumps virus by PCR. Readmitted at 15 mo due to persistent fever and malaise, eventually developed septic shock and metabolic acidosis. Patient recovered from MMR infection. 
STAT2 P4, P5 (Moens et al., 2017) 24, 18 7a, 11 P4: 1 wk after MMR vaccination, the patient developed a morbilliform rash, tonsillitis, conjunctivitis, lymphadenopathy, hepatosplenomegaly, and arthritis. Patient recovered from MMR infection. Patient experienced frequent severe viral infections during the first 3 yr and died at 7 yr of fulminant viral infection. 
P5: 1 wk after MMR vaccination, the patient developed disseminated measles, complicated by hepatitis and pneumonitis. Patient recovered from MMR infection. 
IFNAR2 (Duncan et al., 2015) 13 1.3a 6 d after MMR vaccination, the patient developed a marked injection-site reaction and generalized morbilliform skin rash, recurrent maculopapular rash, fever, and intractable seizures. Patient died on day 81 after vaccination. 
IRF7 (Ciancanelli et al., 2015) 12 9 1 wk after MMR vaccination, the patient developed a rash suggestive of measles. Patient recovered from MMR infection. Patient also suffered from a life-threatening influenza infection at 3 yr of age. 
IRF9 (Hernandez et al., 2018) 16 5 2 wk after MMR vaccination, the patient developed an idiopathic biliary perforation. Patient recovered from MMR infection. Patient also suffered a life-threatening influenza infection at 2 yr of age, parainfluenza virus at age 4, and recurrent fevers without a causative pathogen identified throughout her childhood. 
STAT1 (Burns et al., 2016) 13 2 1 wk after MMR vaccination, patient developed fever, irritability, rash, diarrhea, encephalitis, a hemophagocytic lymphohistiocytosis-like syndrome, and was positive for human herpesvirus 6. Patient was readmitted 7 d later with refusal to walk, unsteady gait, and inflammatory cells in the CSF. Patient recovered from MMR infection. 
IFNAR1 P1 (this report) 12 9 10 d after MMR vaccination, patient developed a generalized exanthema, fever, and encephalitis. Patient recovered from MMR infection. 
a

Deaths.

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