Induction of EAE and Spontaneous Recovery*
| . | . | B10.PL . | . | B10.PLμMT . | . | P** . |
|---|---|---|---|---|---|---|
| Incidence | 16/19‡ | 19/22 | ||||
| Onset day of EAE | 16.2 ± 0.68 (13–21)§ | 15.4 ± 0.92 (9–25) | P = NS | |||
| Maximum disease severity | 2.47 ± 0.21 (1-3.5)∥ | 2.66 ± 0.20 (1.5-5) | P = NS | |||
| Disease at day 40 | 0.44 ± 0.14 (0-1)¶ | 2.03 ± 0.20 (1–5) | P = 0.01 |
| . | . | B10.PL . | . | B10.PLμMT . | . | P** . |
|---|---|---|---|---|---|---|
| Incidence | 16/19‡ | 19/22 | ||||
| Onset day of EAE | 16.2 ± 0.68 (13–21)§ | 15.4 ± 0.92 (9–25) | P = NS | |||
| Maximum disease severity | 2.47 ± 0.21 (1-3.5)∥ | 2.66 ± 0.20 (1.5-5) | P = NS | |||
| Disease at day 40 | 0.44 ± 0.14 (0-1)¶ | 2.03 ± 0.20 (1–5) | P = 0.01 |
B10.PL and B10.PLμMT female mice were inoculated with MBP Ac1-11 emulsified in CFA and observed for signs of EAE.
3/19 B10.PL mice and 3/22 B10.PLμMT mice inoculated with MBP Ac1-11 did not show signs of EAE. These animals were not included in the following statistics (§ ∥ ‡ **). ( ∥ ¶ ) Mean ± SE (range). EAE disease severity was graded in a scale 0–5: 0, no disease; 1, limp tail; 2, hind limb paresis; 3, hind limb paralysis; 4, hind limb and fore limb paralysis; 5, death. All animals were graded daily through day 40.
Student's t test using 34 degrees of freedom was applied to the two groups. P ⩽0.01 is considered significant.