| Shared mechanism between the immune synapse and primary cilia . | Molecular effectors at the primary cilia . | Molecular effectors at the immune synapse . |
|---|---|---|
| Centrosomal docking at the plasma membrane | Distal appendages | Distal appendages |
| CEP83, CEP164, CEP89, SCLT1, C2CD3, LRRC45 | CEP83 | |
| Actin rearrangements | WASH, Arp2/3 | WAVE2, WASp, Arp2/3 |
| Trafficking machinery | IFT proteins, including IFT20, IFT52, IFT57, IFT88, and IFT54 | IFT proteins, including IFT20, IFT52, IFT57, IFT88, and IFT54 |
| GMAP-210 | GMAP-210 | |
| GTPases and GEFs: Rabs, including Rab29, Rab11, and Rab8 | GTPases and GEFs: Rab29, Rab11, Rab8 | |
| ARL3, ARL13B | ARL3, ARL13B | |
| SNAREs: VAMP7 | SNAREs: VAMP7 | |
| Adaptors: MAL | Adaptors: MAL | |
| Hh signaling pathway | PTCH, Hh ligands, SMO, Gli | PTCH, Hh ligands, SMO, Gli |
| Shared mechanism between the immune synapse and primary cilia . | Molecular effectors at the primary cilia . | Molecular effectors at the immune synapse . |
|---|---|---|
| Centrosomal docking at the plasma membrane | Distal appendages | Distal appendages |
| CEP83, CEP164, CEP89, SCLT1, C2CD3, LRRC45 | CEP83 | |
| Actin rearrangements | WASH, Arp2/3 | WAVE2, WASp, Arp2/3 |
| Trafficking machinery | IFT proteins, including IFT20, IFT52, IFT57, IFT88, and IFT54 | IFT proteins, including IFT20, IFT52, IFT57, IFT88, and IFT54 |
| GMAP-210 | GMAP-210 | |
| GTPases and GEFs: Rabs, including Rab29, Rab11, and Rab8 | GTPases and GEFs: Rab29, Rab11, Rab8 | |
| ARL3, ARL13B | ARL3, ARL13B | |
| SNAREs: VAMP7 | SNAREs: VAMP7 | |
| Adaptors: MAL | Adaptors: MAL | |
| Hh signaling pathway | PTCH, Hh ligands, SMO, Gli | PTCH, Hh ligands, SMO, Gli |