| Rank . | Cell line . | Perturbagen . | Dose (μm) . | Duration (h) . | Score . | Perturbed genes . |
|---|---|---|---|---|---|---|
| 1 | MCF7 | Epicatechin monogallate | 10.0 | 6 | 1,000 | GOLGB1, PDE4DIP, TOR1A |
| 2 | PC3 | s1154 | 10.0 | 6 | 0.923 | HMOX1, PDE4DIP |
| 3 | PC3 | BRD-A82197375 | 10.0 | 6 | 0.738 | TOR1A |
| 4 | A375 | ganciclovir | 10.0 | 6 | 0.600 | GOLGB1, HMOX1 |
| 5 | MCF7 | estrone | 10.0 | 6 | 0.554 | HMOX1, PDE4DIP |
| 6 | A549 | GDC-0879 | 3.33 | 24 | 0.431 | HMOX1 |
| 7 | VCAP | sertaconazole_nitrate | 10.0 | 24 | 0.323 | PDE4DIP |
| 8 | BT20 | radicicol | 1.11 | 3 | 0.292 | HMOX1, HYOU1 |
| 9 | VCAP | BRD-A16581344 | 10.0 | 24 | 0.231 | HYOU1, PDE4DIP |
| 10 | A549 | SB-216763 | 10 | 24 | 0.231 | PDE4DIP |
| 11 | VCAP | cetirizine_dihydrochloride | 10.0 | 6 | 0.231 | HYOU1, PDE4DIP |
| 12 | HCC515 | bcl-2_inhibitor | 10.0 | 24 | 0.169 | GOLGB1, HMOX1, TAPT1 |
| 13 | HA1E | betamethasone | 10.0 | 24 | 0.169 | GOLGB1, HMOX1, PDE4DIP |
| 14 | MCF7 | t0513-6584 | 10.0 | 6 | 0.154 | TOR1A |
| 15 | MCF7 | e6_berbamine | 10.0 | 6 | 0.154 | PDE4DIP |
| 16 | A549 | dabrafenib | 0.12 | 24 | 0.154 | HMOX1 |
| 17 | THP1 | BRD-K31342827 | 12.12 | 6 | 0.154 | HMOX1, HYOU1, TAPT1 |
| 18 | A375 | BRD-K19410523 | 10.0 | 6 | 0.154 | HMOX1, PDE4DIP |
| 19 | MCF10A | NVP-AUY922 | 10 | 3 | 0.138 | HMOX1, HYOU1, WFS1 |
| 20 | PC3 | mls-0435429 | 10.0 | 6 | 0.123 | HMOX1, PDE4DIP |
| 21 | BT20 | radicicol | 3.33 | 3 | 0.123 | HMOX1, HYOU1 |
| 22 | HA1E | np-010914 | 10.0 | 6 | 0.108 | ERMP1, HYOU1, PDE4DIP |
| 23 | HME1 | geldanamycin | 3.33 | 3 | 0.108 | HMOX1, HYOU1, PDE4DIP |
| 24 | MCF7 | metergoline | 10.0 | 24 | 0.108 | TOR1A |
| 25 | A549 | HY-11007 | 10 | 24 | 0.108 | TOR1A |
| 26 | MCF7 | BRD-K05593511 | 10.0 | 6 | 0.077 | GOLGB1, PDE4DIP |
| Rank . | Cell line . | Perturbagen . | Dose (μm) . | Duration (h) . | Score . | Perturbed genes . |
|---|---|---|---|---|---|---|
| 1 | MCF7 | Epicatechin monogallate | 10.0 | 6 | 1,000 | GOLGB1, PDE4DIP, TOR1A |
| 2 | PC3 | s1154 | 10.0 | 6 | 0.923 | HMOX1, PDE4DIP |
| 3 | PC3 | BRD-A82197375 | 10.0 | 6 | 0.738 | TOR1A |
| 4 | A375 | ganciclovir | 10.0 | 6 | 0.600 | GOLGB1, HMOX1 |
| 5 | MCF7 | estrone | 10.0 | 6 | 0.554 | HMOX1, PDE4DIP |
| 6 | A549 | GDC-0879 | 3.33 | 24 | 0.431 | HMOX1 |
| 7 | VCAP | sertaconazole_nitrate | 10.0 | 24 | 0.323 | PDE4DIP |
| 8 | BT20 | radicicol | 1.11 | 3 | 0.292 | HMOX1, HYOU1 |
| 9 | VCAP | BRD-A16581344 | 10.0 | 24 | 0.231 | HYOU1, PDE4DIP |
| 10 | A549 | SB-216763 | 10 | 24 | 0.231 | PDE4DIP |
| 11 | VCAP | cetirizine_dihydrochloride | 10.0 | 6 | 0.231 | HYOU1, PDE4DIP |
| 12 | HCC515 | bcl-2_inhibitor | 10.0 | 24 | 0.169 | GOLGB1, HMOX1, TAPT1 |
| 13 | HA1E | betamethasone | 10.0 | 24 | 0.169 | GOLGB1, HMOX1, PDE4DIP |
| 14 | MCF7 | t0513-6584 | 10.0 | 6 | 0.154 | TOR1A |
| 15 | MCF7 | e6_berbamine | 10.0 | 6 | 0.154 | PDE4DIP |
| 16 | A549 | dabrafenib | 0.12 | 24 | 0.154 | HMOX1 |
| 17 | THP1 | BRD-K31342827 | 12.12 | 6 | 0.154 | HMOX1, HYOU1, TAPT1 |
| 18 | A375 | BRD-K19410523 | 10.0 | 6 | 0.154 | HMOX1, PDE4DIP |
| 19 | MCF10A | NVP-AUY922 | 10 | 3 | 0.138 | HMOX1, HYOU1, WFS1 |
| 20 | PC3 | mls-0435429 | 10.0 | 6 | 0.123 | HMOX1, PDE4DIP |
| 21 | BT20 | radicicol | 3.33 | 3 | 0.123 | HMOX1, HYOU1 |
| 22 | HA1E | np-010914 | 10.0 | 6 | 0.108 | ERMP1, HYOU1, PDE4DIP |
| 23 | HME1 | geldanamycin | 3.33 | 3 | 0.108 | HMOX1, HYOU1, PDE4DIP |
| 24 | MCF7 | metergoline | 10.0 | 24 | 0.108 | TOR1A |
| 25 | A549 | HY-11007 | 10 | 24 | 0.108 | TOR1A |
| 26 | MCF7 | BRD-K05593511 | 10.0 | 6 | 0.077 | GOLGB1, PDE4DIP |
The table highlights compounds, ordered according to their statistical scoring, which perturb gene subsets of the input signature (last column), when administered in the indicated cell line. The input gene signature has been derived from the BioInfoMiner analysis, using the MGIMP ontology, for the CoV-2 secretome (87 protein interactions).