Table 1.
Cell types in the brain with lipid droplets
SettingCell typeReferencea
Development Oligodendrocytes Hayashi and Su, 2004  
Glia (DrosophilaBailey et al., 2015  
Astrocytes Lucken-Ardjomande Häsler et al., 2014  
Aging Neurons Shimabukuro et al., 2016  
Microglia Shimabukuro et al., 2016  
Marschallinger et al., 2020  
Astrocytes Shimabukuro et al., 2016  
Ependymal cells Shimabukuro et al., 2016  
Alzheimer’s disease Neurons Yang et al., 2014  
Glia (DrosophilaLiu et al., 2017  
Myeloid cells Derk et al., 2018  
Ependymal cells Hamilton et al., 2015  
Astrocytes Qi et al., 2021  
HSP Neurons Papadopoulos et al., 2015  
Renvoisé et al., 2016  
Astrocytes Mou et al., 2020  
Amyotrophic lateral sclerosis Astrocytes Chaves-Filho et al., 2019  
Jiménez-Riani et al., 2017  
Parkinson’s disease Neurons Brekk et al., 2020  
Cole et al., 2002  
Microglia Brekk et al., 2020  
Huntington’s disease Neurons Martinez-Vicente et al., 2010  
Multiple sclerosis Neurons Kim et al., 2015  
Microglia Grajchen et al., 2018  
Stroke Astrocytes Ioannou et al., 2019a  
Microglia Gasparovic et al., 2001  
Ioannou et al., 2019a  
SettingCell typeReferencea
Development Oligodendrocytes Hayashi and Su, 2004  
Glia (DrosophilaBailey et al., 2015  
Astrocytes Lucken-Ardjomande Häsler et al., 2014  
Aging Neurons Shimabukuro et al., 2016  
Microglia Shimabukuro et al., 2016  
Marschallinger et al., 2020  
Astrocytes Shimabukuro et al., 2016  
Ependymal cells Shimabukuro et al., 2016  
Alzheimer’s disease Neurons Yang et al., 2014  
Glia (DrosophilaLiu et al., 2017  
Myeloid cells Derk et al., 2018  
Ependymal cells Hamilton et al., 2015  
Astrocytes Qi et al., 2021  
HSP Neurons Papadopoulos et al., 2015  
Renvoisé et al., 2016  
Astrocytes Mou et al., 2020  
Amyotrophic lateral sclerosis Astrocytes Chaves-Filho et al., 2019  
Jiménez-Riani et al., 2017  
Parkinson’s disease Neurons Brekk et al., 2020  
Cole et al., 2002  
Microglia Brekk et al., 2020  
Huntington’s disease Neurons Martinez-Vicente et al., 2010  
Multiple sclerosis Neurons Kim et al., 2015  
Microglia Grajchen et al., 2018  
Stroke Astrocytes Ioannou et al., 2019a  
Microglia Gasparovic et al., 2001  
Ioannou et al., 2019a  
a

Relevant literature linking lipid droplets to distinct cell types in development, aging, or disease. Includes studies using in vitro and/or in vivo model systems.

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