Summary of the phenotypes of caspase-3 deficient mice
| Genotype . | Genetic background . | Phenotype . | Mechanism . | Ref . |
|---|---|---|---|---|
| Caspase-3−/− | B6.129S1 | Reduction in total skeletal muscle mass; Myoblasts display a differentiation defect | Proteolytic function of caspase-3 activates MST1 and leads to myoblast differentiation | Fernando et al. (2002) |
| Caspase-3−/− | C57Bl/6 | Deletion preserves hematopoietic stem cell pool but perturbs their differentiation without affecting cell viability | Caspase-3 alters signal transduction by limiting activation of the Ras-Raf-MEK-ERK pathway | Janzen et al. (2008) |
| Caspase-3−/− | C57Bl/6 | Defects in skin wound healing and in liver regeneration | Caspase-3 stimulates production of PGE2, to promote cell proliferation and tissue regeneration, | Li et al. (2010b) |
| Caspase-3−/− | C57BL/6 | Decreased incidence of chemically induced skin cancer | Caspase-3 activation of ENDOG enhances radiation-induced DNA damage and oncogenic transformation | Liu et al. (2015) |
| Caspase-3−/− | B6.129S1 | Embryonic lethal, defective brain development | NA | Kuida et al. (1996) |
| Caspase-3−/− | C57BL/6 | Increased renal lesions and mild splenomegaly | Increased expression of inflammatory Casp12, was observed in these Caspase-3 KO kidneys | Suzuki et al. (2020) |
| Caspase-3−/−7−/− (conditional cardiac-specific KO mice) | C57BL/6 | Hypoplastic neonatal heart with reduced number of cardiomyocytes | Caspase 3 and 7 regulate expression of genes involved in cell cycle independent of their proteolytic activity | Cardona et al. (2015) |
| Caspase-3−/−7−/− (conditional intestinal-specific KO mice) | C57BL/6N | Normal intestinal development | NA | Ghazavi et al. (2022) |
| Caspase-3−/− | B6.129S1 | Delayed ossification and decreased bone mineral density | Caspase-3 regulates the TGF-β/Smad2 signaling pathway and cellular senescence | Miura et al. (2004) |
| Caspase-3−/− | B6.129S1 | Diminished cell proliferation and reduced sebaceous gland size | Caspase-3 cleaves α-catenin and facilitates activation and nuclear translocation of YAP1 | Yosefzon et al. (2018) |
| Genotype . | Genetic background . | Phenotype . | Mechanism . | Ref . |
|---|---|---|---|---|
| Caspase-3−/− | B6.129S1 | Reduction in total skeletal muscle mass; Myoblasts display a differentiation defect | Proteolytic function of caspase-3 activates MST1 and leads to myoblast differentiation | Fernando et al. (2002) |
| Caspase-3−/− | C57Bl/6 | Deletion preserves hematopoietic stem cell pool but perturbs their differentiation without affecting cell viability | Caspase-3 alters signal transduction by limiting activation of the Ras-Raf-MEK-ERK pathway | Janzen et al. (2008) |
| Caspase-3−/− | C57Bl/6 | Defects in skin wound healing and in liver regeneration | Caspase-3 stimulates production of PGE2, to promote cell proliferation and tissue regeneration, | Li et al. (2010b) |
| Caspase-3−/− | C57BL/6 | Decreased incidence of chemically induced skin cancer | Caspase-3 activation of ENDOG enhances radiation-induced DNA damage and oncogenic transformation | Liu et al. (2015) |
| Caspase-3−/− | B6.129S1 | Embryonic lethal, defective brain development | NA | Kuida et al. (1996) |
| Caspase-3−/− | C57BL/6 | Increased renal lesions and mild splenomegaly | Increased expression of inflammatory Casp12, was observed in these Caspase-3 KO kidneys | Suzuki et al. (2020) |
| Caspase-3−/−7−/− (conditional cardiac-specific KO mice) | C57BL/6 | Hypoplastic neonatal heart with reduced number of cardiomyocytes | Caspase 3 and 7 regulate expression of genes involved in cell cycle independent of their proteolytic activity | Cardona et al. (2015) |
| Caspase-3−/−7−/− (conditional intestinal-specific KO mice) | C57BL/6N | Normal intestinal development | NA | Ghazavi et al. (2022) |
| Caspase-3−/− | B6.129S1 | Delayed ossification and decreased bone mineral density | Caspase-3 regulates the TGF-β/Smad2 signaling pathway and cellular senescence | Miura et al. (2004) |
| Caspase-3−/− | B6.129S1 | Diminished cell proliferation and reduced sebaceous gland size | Caspase-3 cleaves α-catenin and facilitates activation and nuclear translocation of YAP1 | Yosefzon et al. (2018) |