Table 1. Summary of direct targets of... | Rockefeller University Press

Table 1.

Summary of direct targets of CASPASE-3 in non-apoptotic settings

Protein	Cleavage outcome	Effect on cells	Cell type studied	Organism	Mechanism	Reference
PKC delta	Activation	Enhanced angiogenesis and tumor repopulation	Colorectal, pancreatic cancer	Human	Activation of AKT-VEGFA pathway	Cheng et al. (2019), Cheng et al. (2015)
ROCK1	Activation	Terminal maturation	Erythroblasts	Mouse	Phosphorylation of the light chain of myosin II	Gabet et al. (2011)
A-catenin	Inactivation	Increased cell proliferation and organ size	Epidermal cells	Mouse	Increased nuclear localization of YAP1	Yosefzon et al. (2018)
Retinoblastoma (Rb) protein	Inactivation	Nuclear reprogramming in iPSC induction	Fibroblasts	Human	Cell cycle progression by Rb inactivation	Li et al. (2010a)
iPLA2	Activation	Increased cell migration	Ovarian cancer cells	Human	Activation of AKT pathway	Zhao et al. (2006)
iPLA2	Activation	Increased tumor repopulation	Breast cancer cells	Mouse, human	Enhanced paracrine signaling	Huang et al. (2011)
MST1	Activation	Skeletal muscle differentiation	Myoblasts	Mouse	Activation of MAPK pathway	Fernando et al. (2002)
Caspase-activated DNase (CAD)	Activation	Skeletal muscle differentiation	Myoblasts	Mouse	Induction of DNA strand breaks	Larsen et al. (2010)
Pax7	Inactivation	Self-renewal of satellite cells	Satellite cells	Mouse	NA	Dick et al. (2015)
hnRNP K	Inactivation	Terminal maturation	Erythroblasts	Mouse	NA	Naarmann-de Vries et al. (2013)
ULK1	Inactivation	Leukemogenesis	Mouse fetal liver cells	Mouse	ULK1-dependant autophagy induction	Man et al. (2017)
DUSP8	Inactivation	Cell proliferation and wound healing	Hair follicle stem cells	Mouse	p38-Mapk -mediated Wnt3 signaling	Ankawa et al. (2021)

Protein	Cleavage outcome	Effect on cells	Cell type studied	Organism	Mechanism	Reference
PKC delta	Activation	Enhanced angiogenesis and tumor repopulation	Colorectal, pancreatic cancer	Human	Activation of AKT-VEGFA pathway	Cheng et al. (2019), Cheng et al. (2015)
ROCK1	Activation	Terminal maturation	Erythroblasts	Mouse	Phosphorylation of the light chain of myosin II	Gabet et al. (2011)
A-catenin	Inactivation	Increased cell proliferation and organ size	Epidermal cells	Mouse	Increased nuclear localization of YAP1	Yosefzon et al. (2018)
Retinoblastoma (Rb) protein	Inactivation	Nuclear reprogramming in iPSC induction	Fibroblasts	Human	Cell cycle progression by Rb inactivation	Li et al. (2010a)
iPLA2	Activation	Increased cell migration	Ovarian cancer cells	Human	Activation of AKT pathway	Zhao et al. (2006)
iPLA2	Activation	Increased tumor repopulation	Breast cancer cells	Mouse, human	Enhanced paracrine signaling	Huang et al. (2011)
MST1	Activation	Skeletal muscle differentiation	Myoblasts	Mouse	Activation of MAPK pathway	Fernando et al. (2002)
Caspase-activated DNase (CAD)	Activation	Skeletal muscle differentiation	Myoblasts	Mouse	Induction of DNA strand breaks	Larsen et al. (2010)
Pax7	Inactivation	Self-renewal of satellite cells	Satellite cells	Mouse	NA	Dick et al. (2015)
hnRNP K	Inactivation	Terminal maturation	Erythroblasts	Mouse	NA	Naarmann-de Vries et al. (2013)
ULK1	Inactivation	Leukemogenesis	Mouse fetal liver cells	Mouse	ULK1-dependant autophagy induction	Man et al. (2017)
DUSP8	Inactivation	Cell proliferation and wound healing	Hair follicle stem cells	Mouse	p38-Mapk -mediated Wnt3 signaling	Ankawa et al. (2021)