Table 1.
Comparison of relative phospholipid compositions in native ROS membrane domainsa
PhospholipidRhodopsinABCA4PRPH2/ROM1ROS diskbROS PMb
 Copurifying in SMALPs Isolated in ricin/gold separation 
PC 39.6 ± 3.8 60.9 ± 15.6 60.1 ± 11.8 45.3 ± 3.2 65.1 ± 3.8 
PE 54.0 ± 2.7 34.7 ± 17.3 37.0 ± 11.4 41.6 ± 2.6 10.6 ± 2.8 
PG 0.2 ± 0.1 0.1 ± 0.1 0.1 ± 0.03 
PI 1.1 ± 0.6 0.6 ± 0.7 0.2 ± 0.1 2.5 ± 0.8 <1.0 
PS 5.1 ± 3.4 3.7 ± 2.9 2.6 ± 0.6 13.7 ± 2.1 24.1 ± 2.8 
PhospholipidRhodopsinABCA4PRPH2/ROM1ROS diskbROS PMb
 Copurifying in SMALPs Isolated in ricin/gold separation 
PC 39.6 ± 3.8 60.9 ± 15.6 60.1 ± 11.8 45.3 ± 3.2 65.1 ± 3.8 
PE 54.0 ± 2.7 34.7 ± 17.3 37.0 ± 11.4 41.6 ± 2.6 10.6 ± 2.8 
PG 0.2 ± 0.1 0.1 ± 0.1 0.1 ± 0.03 
PI 1.1 ± 0.6 0.6 ± 0.7 0.2 ± 0.1 2.5 ± 0.8 <1.0 
PS 5.1 ± 3.4 3.7 ± 2.9 2.6 ± 0.6 13.7 ± 2.1 24.1 ± 2.8 

PI, phosphatidylinositol.

a

Total values for all phospholipids detected in positive mode of LC/MS were used to estimate the relative phospholipid composition in each SMALP-extracted membrane region. Each value is presented as a mean percentage ± SD.

b

Comparison values from prior ROS disk and PM isolations are taken from Boesze-Battaglia and Albert (1992). Values for PG not included in Boesze-Battaglia and Albert (1992) are noted with “-,” and “< 1.0” refers to a value not reported for being <1%.

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