Table 1.
Diseases caused by mutations in LTPs
LTPDiseaseReferences
α-Tocopherol transfer protein Ataxia with isolated vitamin E deficiency (OMIM 277460) Ouahchi et al., 1995  
Microsomal triglyceride transfer protein Abetalipoproteinemia (OMIM 200100) Shoulders et al., 1993  
Niemann-Pick C1 protein Niemann-Pick disease type C1 (OMIM 257220) Carstea et al., 1997  
Niemann-Pick C2 protein Niemann-Pick disease type C2 (OMIM 607625) Naureckiene et al., 2000  
Steroid acute regulatory protein Lipoid congenital adrenal hyperplasia (OMIM 201710) Lin et al., 1995  
Vps13A Chorea-acanthocytosis (OMIM 200150) Rampoldi et al., 2001  
Vps13B Cohen syndrome (OMIM 216550) Kolehmainen et al., 2003  
Vps13C Early onset Parkinson’s disease (OMIM 616840) Lesage et al., 2016  
Vps13D Spastic ataxia (OMIM 607317) Gauthier et al., 2018; Seong et al., 2018  
LTPDiseaseReferences
α-Tocopherol transfer protein Ataxia with isolated vitamin E deficiency (OMIM 277460) Ouahchi et al., 1995  
Microsomal triglyceride transfer protein Abetalipoproteinemia (OMIM 200100) Shoulders et al., 1993  
Niemann-Pick C1 protein Niemann-Pick disease type C1 (OMIM 257220) Carstea et al., 1997  
Niemann-Pick C2 protein Niemann-Pick disease type C2 (OMIM 607625) Naureckiene et al., 2000  
Steroid acute regulatory protein Lipoid congenital adrenal hyperplasia (OMIM 201710) Lin et al., 1995  
Vps13A Chorea-acanthocytosis (OMIM 200150) Rampoldi et al., 2001  
Vps13B Cohen syndrome (OMIM 216550) Kolehmainen et al., 2003  
Vps13C Early onset Parkinson’s disease (OMIM 616840) Lesage et al., 2016  
Vps13D Spastic ataxia (OMIM 607317) Gauthier et al., 2018; Seong et al., 2018  

OMIM, Online Mendelian Inheritance in Man number.

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