| RNA/DNA virus . | Family, genus . | Virus . | Host factor genes . | Host processes . | References . |
|---|---|---|---|---|---|
| RNA | Flaviviridae, Flavivirus | West Nile | EMC2, EMC3, SEL1L, DERL2, UBE2G2, UBE2J1, HRD1, STT3A, SEC63, SPCS1, SPC3 | ERAD, endoplasmic reticulum-associated signal peptidase complex (SPCS) | (Ma et al., 2015); (Zhang et al., 2016) |
| Flaviviridae, Flavivirus | Dengue | STT3A, STT3B, OSTC, EMC2, EMC4, EMC3, SSR1, SSR2, SSR3, SEC61A1, OST4, MAGT1 | ERAD, SPCS, OST | (Marceau et al., 2016); (Lin et al., 2017) | |
| Flaviviridae, Flavivirus | Yellow fever | IFI6, IFNAR1, IFNAR2, IRF9, TYK2, JAK1, STAT2, PCBP1, ECD, SNRPF, PCF11, SNRPD1, HSPA5 | IFN-stimulated genes (ISG)/IFN pathway, RNA processing | (Richardson et al., 2018) | |
| Flaviviridae, Flavivirus | Zika | AXL, EMC1, EMC2, EMC3, SSR3, RABGEF1, MMGT1 | Viral entry, ERAD, SPCS, endocytosis | (Savidis et al., 2016); (Li et al., 2019) | |
| Flaviviridae, Hepacivirus | Hepatitis C | CD81, CLDN1, OCLN, MIR122, PPIA, RFK, FLAD ELAVL1, SSRD | Viral entry, RNA-binding proteins/mRNA stabilization, FAD metabolism, peptidyl-prolyl isomerase | (Marceau et al., 2016) | |
| Filoviridae, Ebolavirus | Zaire Ebola | NPC1, SPNS1, SLC30AI, VPS16, VPS18, VPS33A, KLHDC3, STARD13, GNPTAB | Viral entry, lysosomal transport, multisubunit tethering complexes (MTCs) in the endolysosomal pathway (HOPS complex) | (Flint et al., 2019) | |
| Caliciviridae, Norovirus | Murine norovirus | CD300lf, CD300ld | Viral entry | (Orchard et al., 2016); (Haga et al., 2016) | |
| Picornaviridae, Enterovirus | Rhinovirus | SETD3, PLA2G16, CSDE1 | ISG/IFN pathway, viral entry, translation (IRES) | (Diep et al., 2019) | |
| Picornaviridae, Hepatovirus | Hepatitis A | GNE, CMAS, SLC35A1, UGCG, ST3GAL5, VPS4A, UFM1, UBA5, UFL1, UFC1, UFSP2, PAPD5, PAPD7, ZCCHC14, PTBP1, EIF4B, EIF3C, EIF3CL | Sialic acid and ganglioside biosynthesis, translation initiation, IRES-mediated translation, endosomal sorting (ESCRT), Trf4/5–Air1/2–Mtr4 polyadenylation (TRAMP) complex, UFMylation, polyadenylation | (Kulsuptrakul et al., 2020) | |
| Orthomyxoviridae, Alphainfluenzavirus | Influenza A | SLC35A1, WDR7, EXOC4, VHL, TMEM38A, ATP6AP1 DPAGT1, cap methyltransferase 1 (CMTR1), SRP19, | Sialic acid biosynthesis and transport, N-glycan biosynthesis, UPS, v-type-ATPase, RNA processing, protein export | (Han et al., 2018); (Li et al., 2020) | |
| Coronaviridae, Betacoronavirus | SARS-CoV-2 | ACE2, CTSL, switch/sucrose nonfermenting–related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4), ARID1A, SMARCE1, KDM6A, DYRK1A, UBXN7, small body size/mothers against the decapentaplegic 4 (SMAD4), HMGB1-like; HIRAa, CABINa, ASF1Aa | Viral entry and processing, chromatin remodeling, histone methylation, UPS, TGF-β signaling, alarmin | (Wei et al., 2020) | |
| RNA, retrovirus | Retroviridae, Lentivirus | HIV | CD4, CCR5, TPST2, SLC35B2, ALCAM, myc-induced nuclear antigen 53 (MINA53)a | Viral entry, post-translational modification (sulfation), cell–cell adhesion, histone modification, latency | (Park et al., 2017); (Huang et al., 2019) |
| DNA | Hepadnaviridae, Orthohepadnavirus | Hepatitis B | ZCCHC14, (PAPD5, PAPD7), NXT1, ENY2, DCAF7a, UBE2J1a, UBE2J2a, RNF139a | Polyadenylation, nuclear export, UPS | (Hyrina et al., 2019) |
| Herpesviridae, Lymphocryptovirus | Epstein-Barr | CD19b, CD81b, IRF2b, IRF4b, SYKb, BATFb,CFLARb, RBPJb, RelAb, RFN31b, CCND2b, CDK6 b, CDK4c, CCND3c, BCL6c | Cell cycle, LMP1/LMP2a signaling, PI3K/AKT signaling, tumor suppression pathways | (Ma et al., 2017) |
| RNA/DNA virus . | Family, genus . | Virus . | Host factor genes . | Host processes . | References . |
|---|---|---|---|---|---|
| RNA | Flaviviridae, Flavivirus | West Nile | EMC2, EMC3, SEL1L, DERL2, UBE2G2, UBE2J1, HRD1, STT3A, SEC63, SPCS1, SPC3 | ERAD, endoplasmic reticulum-associated signal peptidase complex (SPCS) | (Ma et al., 2015); (Zhang et al., 2016) |
| Flaviviridae, Flavivirus | Dengue | STT3A, STT3B, OSTC, EMC2, EMC4, EMC3, SSR1, SSR2, SSR3, SEC61A1, OST4, MAGT1 | ERAD, SPCS, OST | (Marceau et al., 2016); (Lin et al., 2017) | |
| Flaviviridae, Flavivirus | Yellow fever | IFI6, IFNAR1, IFNAR2, IRF9, TYK2, JAK1, STAT2, PCBP1, ECD, SNRPF, PCF11, SNRPD1, HSPA5 | IFN-stimulated genes (ISG)/IFN pathway, RNA processing | (Richardson et al., 2018) | |
| Flaviviridae, Flavivirus | Zika | AXL, EMC1, EMC2, EMC3, SSR3, RABGEF1, MMGT1 | Viral entry, ERAD, SPCS, endocytosis | (Savidis et al., 2016); (Li et al., 2019) | |
| Flaviviridae, Hepacivirus | Hepatitis C | CD81, CLDN1, OCLN, MIR122, PPIA, RFK, FLAD ELAVL1, SSRD | Viral entry, RNA-binding proteins/mRNA stabilization, FAD metabolism, peptidyl-prolyl isomerase | (Marceau et al., 2016) | |
| Filoviridae, Ebolavirus | Zaire Ebola | NPC1, SPNS1, SLC30AI, VPS16, VPS18, VPS33A, KLHDC3, STARD13, GNPTAB | Viral entry, lysosomal transport, multisubunit tethering complexes (MTCs) in the endolysosomal pathway (HOPS complex) | (Flint et al., 2019) | |
| Caliciviridae, Norovirus | Murine norovirus | CD300lf, CD300ld | Viral entry | (Orchard et al., 2016); (Haga et al., 2016) | |
| Picornaviridae, Enterovirus | Rhinovirus | SETD3, PLA2G16, CSDE1 | ISG/IFN pathway, viral entry, translation (IRES) | (Diep et al., 2019) | |
| Picornaviridae, Hepatovirus | Hepatitis A | GNE, CMAS, SLC35A1, UGCG, ST3GAL5, VPS4A, UFM1, UBA5, UFL1, UFC1, UFSP2, PAPD5, PAPD7, ZCCHC14, PTBP1, EIF4B, EIF3C, EIF3CL | Sialic acid and ganglioside biosynthesis, translation initiation, IRES-mediated translation, endosomal sorting (ESCRT), Trf4/5–Air1/2–Mtr4 polyadenylation (TRAMP) complex, UFMylation, polyadenylation | (Kulsuptrakul et al., 2020) | |
| Orthomyxoviridae, Alphainfluenzavirus | Influenza A | SLC35A1, WDR7, EXOC4, VHL, TMEM38A, ATP6AP1 DPAGT1, cap methyltransferase 1 (CMTR1), SRP19, | Sialic acid biosynthesis and transport, N-glycan biosynthesis, UPS, v-type-ATPase, RNA processing, protein export | (Han et al., 2018); (Li et al., 2020) | |
| Coronaviridae, Betacoronavirus | SARS-CoV-2 | ACE2, CTSL, switch/sucrose nonfermenting–related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4), ARID1A, SMARCE1, KDM6A, DYRK1A, UBXN7, small body size/mothers against the decapentaplegic 4 (SMAD4), HMGB1-like; HIRAa, CABINa, ASF1Aa | Viral entry and processing, chromatin remodeling, histone methylation, UPS, TGF-β signaling, alarmin | (Wei et al., 2020) | |
| RNA, retrovirus | Retroviridae, Lentivirus | HIV | CD4, CCR5, TPST2, SLC35B2, ALCAM, myc-induced nuclear antigen 53 (MINA53)a | Viral entry, post-translational modification (sulfation), cell–cell adhesion, histone modification, latency | (Park et al., 2017); (Huang et al., 2019) |
| DNA | Hepadnaviridae, Orthohepadnavirus | Hepatitis B | ZCCHC14, (PAPD5, PAPD7), NXT1, ENY2, DCAF7a, UBE2J1a, UBE2J2a, RNF139a | Polyadenylation, nuclear export, UPS | (Hyrina et al., 2019) |
| Herpesviridae, Lymphocryptovirus | Epstein-Barr | CD19b, CD81b, IRF2b, IRF4b, SYKb, BATFb,CFLARb, RBPJb, RelAb, RFN31b, CCND2b, CDK6 b, CDK4c, CCND3c, BCL6c | Cell cycle, LMP1/LMP2a signaling, PI3K/AKT signaling, tumor suppression pathways | (Ma et al., 2017) |
Genes listed are proviral unless annotated as antiviral (a) genes. Screens for Epstein-Barr virus were performed in lymphoblastoid (b) or Burkitt lymphoma (c) cell lines.