Table 1. Overview of different... | Rockefeller University Press

Table 1.

Overview of different properties of iPRRs

iPRR	iPRR expression	iPRR structure	Signaling pathway	Endogenous ligand	Endogenous ligand expression	Microbial ligand	Activating receptor for the same ligand
CD300a/f	Broad on immune cells, upregulated on activation	Ig-like	ITIM	PS, PE	Exposed in programmed cell death	—	Tim4
CEACAM‑1	Broad on immune, epithelial, and endothelial cells	Ig-like	ITIM	CEACAM1 and other CEACAMs	Constitutive	Ig fold proteins	Other CEACAMs
LAIR-1	Broad on immune cells; on activation, upregulated on neutrophils and downregulated on T cells	Ig-like	ITIM	Collagen	Constitutive	—	OSCAR
LILRB1 (CD85j)	Neutrophil, monocyte, dendritic cell, and NK cell, upregulated on activation	Ig-like	ITIM	S100 proteins	Upon cell damage	—	TLR4, RAGE
LILRB3 (CD85a)	Neutrophil, monocyte, dendritic cell	Ig-like	ITIM	Unknown cytokeratin-associated ligand	Upon cell damage	Unknown in S. aureus (LTA shown for mice ortholog PIR-B)	TLR2/6
PVR	Dendritic cell, upregulated on activation	Ig-like	ITIM	Nectin-3	Constitutive	Poliovirus	—
Siglec 2, 3, 5–11	Broad on immune cells, differs per receptor	Ig-like	ITIM	Sialic acids	Constitutive	Sialic acids	Siglec 14–16
Siglec 2, 3, 5–11	Broad on immune cells, differs per receptor	Ig-like	ITIM	Hsp70	Upon cell damage	—	TLR4, RAGE
Siglec 10	B cell, eosinophil, monocyte	Ig-like	ITIM	HMGB1, Hsp90	Upon cell damage	—	TLR4, RAGE
SIRL-1	Neutrophil, monocyte, downregulated on activation	Ig-like	ITIM	LL-37, S100 proteins	Upon cell damage and immune activation	Phenol-soluble modulins of Staphylococcus	TLR4, RAGE, FPR2
TIGIT	T cell, NK cell, upregulated on activation	Ig-like	ITIM	DNAM-1, TIGIT	TIGIT upregulated on activation	Unknown in F. nucleatum	DNAM-1

iPRR	iPRR expression	iPRR structure	Signaling pathway	Endogenous ligand	Endogenous ligand expression	Microbial ligand	Activating receptor for the same ligand
CD300a/f	Broad on immune cells, upregulated on activation	Ig-like	ITIM	PS, PE	Exposed in programmed cell death	—	Tim4
CEACAM‑1	Broad on immune, epithelial, and endothelial cells	Ig-like	ITIM	CEACAM1 and other CEACAMs	Constitutive	Ig fold proteins	Other CEACAMs
LAIR-1	Broad on immune cells; on activation, upregulated on neutrophils and downregulated on T cells	Ig-like	ITIM	Collagen	Constitutive	—	OSCAR
LILRB1 (CD85j)	Neutrophil, monocyte, dendritic cell, and NK cell, upregulated on activation	Ig-like	ITIM	S100 proteins	Upon cell damage	—	TLR4, RAGE
LILRB3 (CD85a)	Neutrophil, monocyte, dendritic cell	Ig-like	ITIM	Unknown cytokeratin-associated ligand	Upon cell damage	Unknown in S. aureus (LTA shown for mice ortholog PIR-B)	TLR2/6
PVR	Dendritic cell, upregulated on activation	Ig-like	ITIM	Nectin-3	Constitutive	Poliovirus	—
Siglec 2, 3, 5–11	Broad on immune cells, differs per receptor	Ig-like	ITIM	Sialic acids	Constitutive	Sialic acids	Siglec 14–16
Siglec 2, 3, 5–11	Broad on immune cells, differs per receptor	Ig-like	ITIM	Hsp70	Upon cell damage	—	TLR4, RAGE
Siglec 10	B cell, eosinophil, monocyte	Ig-like	ITIM	HMGB1, Hsp90	Upon cell damage	—	TLR4, RAGE
SIRL-1	Neutrophil, monocyte, downregulated on activation	Ig-like	ITIM	LL-37, S100 proteins	Upon cell damage and immune activation	Phenol-soluble modulins of Staphylococcus	TLR4, RAGE, FPR2
TIGIT	T cell, NK cell, upregulated on activation	Ig-like	ITIM	DNAM-1, TIGIT	TIGIT upregulated on activation	Unknown in F. nucleatum	DNAM-1

OSCAR, osteoclast-associated Ig-like receptor; PVR, poliovirus receptor; RAGE, receptor for advanced glycation end products.