Table 1.
Examples of micropeptides codified by human lncRNAs
Name (abbreviation)Number of amino acidsFunctionlncRNA Reference
Myoregulin (MRLN) 46 Regulates Ca2+ handling by inhibiting the pump activity of SERCA LINC00948 Anderson et al., 2015  
Small regulatory polypeptide of amino acid response (SPAR) 90 Regulates mTORC1 and muscle regeneration LINC00961 Matsumoto et al., 2017  
Non-annotated P-body dissociating polypeptide (NOBODY) 68 Interacts with mRNA-decapping proteins, which are the molecular components of the first enzymatic step in the 5′-to-3′ mRNA decay pathway LINC01420 D’Lima et al., 2017  
HOXB cluster antisense RNA 3 peptides (HOXB-AS3 peptide) 53 Suppresses colon cancer growth; competitively binds to the arginine residue in RGG motif of hnRNP A1 antagonizing its regulation of pyruvate kinase splicing; low levels correlate with poor prognosis HOXB-AS3 Huang et al., 2017  
Exon 2 of LINC-PINT endogenous circRNA (PINT87aa) 87 Suppresses glioblastoma cell proliferation by interaction with polymerase associated factor complex and inhibition of transcriptional elongation of multiple oncogenes Circular form of LINC-PINT Zhang et al., 2018  
Name (abbreviation)Number of amino acidsFunctionlncRNA Reference
Myoregulin (MRLN) 46 Regulates Ca2+ handling by inhibiting the pump activity of SERCA LINC00948 Anderson et al., 2015  
Small regulatory polypeptide of amino acid response (SPAR) 90 Regulates mTORC1 and muscle regeneration LINC00961 Matsumoto et al., 2017  
Non-annotated P-body dissociating polypeptide (NOBODY) 68 Interacts with mRNA-decapping proteins, which are the molecular components of the first enzymatic step in the 5′-to-3′ mRNA decay pathway LINC01420 D’Lima et al., 2017  
HOXB cluster antisense RNA 3 peptides (HOXB-AS3 peptide) 53 Suppresses colon cancer growth; competitively binds to the arginine residue in RGG motif of hnRNP A1 antagonizing its regulation of pyruvate kinase splicing; low levels correlate with poor prognosis HOXB-AS3 Huang et al., 2017  
Exon 2 of LINC-PINT endogenous circRNA (PINT87aa) 87 Suppresses glioblastoma cell proliferation by interaction with polymerase associated factor complex and inhibition of transcriptional elongation of multiple oncogenes Circular form of LINC-PINT Zhang et al., 2018  

SECA, sarcoplasmic reticulum Ca2+-ATPase; hnRNP, heterogeneous nuclear ribonucleoprotein; circRNA, circular RNA.

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