Dark blue, downregulated signature genes; light blue, additional downregulated genes; orange, upregulated signature genes; yellow, additional upregulated genes. *, these papers extend the profiles of defined clusters, or report a novel cluster. To show the difference between DAM1 and DAM2, only the top genes that were used for this characterization are listed. MGnD, microglial neurodegenerative phenotype; ARM, activated response microglia; IRM, IFN response microglia; WAM, white matter–associated microglia; IFN, IFN-I imprinted; MHC, MHC expressing; Cyc-M, (G)2/M phase–enriched cluster (proliferating microglia).