Table 4. Analysis of enrichment in NFKB1... | Rockefeller University Press

Table 4.

Analysis of enrichment in NFKB1 variants experimentally demonstrated to be deleterious

Cohort	Total exomes	Exomes with deleterious variant	Fisher’s test	OR (95% CI)
HGID-CVID	305	7	2.78 × 10⁻¹⁵	697.9 (133.2–8,192)
gnomAD control	60,146	2^a	2.78 × 10⁻¹⁵	697.9 (133.2–8,192)
HGID-CVID EUR	220	5	5.73 × 10⁻¹¹	∞ (102.2–∞)
gnomAD control NFE	24,146	0	5.73 × 10⁻¹¹	∞ (102.2–∞)

Cohort	Total exomes	Exomes with deleterious variant	Fisher’s test	OR (95% CI)
HGID-CVID	305	7	2.78 × 10⁻¹⁵	697.9 (133.2–8,192)
gnomAD control	60,146	2^a	2.78 × 10⁻¹⁵	697.9 (133.2–8,192)
HGID-CVID EUR	220	5	5.73 × 10⁻¹¹	∞ (102.2–∞)
gnomAD control NFE	24,146	0	5.73 × 10⁻¹¹	∞ (102.2–∞)

EUR, European; NFE, non-Finnish European.

One variant has been reported in patients with CVID.