Table 2.
Validated small compounds that block IL-1β–induced INAVA condensates
Z-scoreCompoundMechanismIC50 (μM)
−2.52 Cycloheximide Protein synthesis inhibitor 0.16 
−2.51 INK-128 mTOR inhibitor 0.04 
−2.51 K-252a PKA/C/G inhibitor 2.63 
−2.51 PDGF receptor tyrosine kinase inhibitor III  6.71 
−2.50 Anisomycin Protein synthesis inhibitor 0.06 
−2.49 Lycorine Protein synthesis inhibitor 3.86 
−2.48 5z-7-oxozeaenol TAK1 inhibitor 0.09 
−2.47 NVP-BHG712 EPHB4 inhibitor 1.3 
−2.47 DCC-2036 Bcr-Abl kinase/TIE/VEGF receptor inhibitor 2.0 
−2.47 GDC-0980 mTOR inhibitor 2.2 
−2.47 p38 MAPK inhibitor VIII p38 MAPK inhibitor 0.06 
−2.46 PD 169316 p38 MAPK inhibitor 0.31 
−2.46 BX795 TBK1/PDK1 inhibitor 2.3 
−2.45 PI-3Kα inhibitor IV mTOR inhibitor 3.95 
−2.45 RWJ-67657 p38 MAPK inhibitor 0.07 
−2.45 OTSSP167 MELK inhibitor 0.05 
−2.45 GNE-493 mTOR inhibitor 1.06 
−2.45 LY2228820 p38 MAPK inhibitor 0.05 
−2.44 Emetine Protein synthesis inhibitor 0.03 
−2.44 IKK-2 inhibitor XI  26.9 
−2.44 AV951 VEGF receptor inhibitor 166.3 
−2.44 SB203580 p38 MAPK inhibitor 2.4 
−2.44 KW-2449 FLT3 inhibitor 63.7 
−2.44 AMG-47a LCK inhibitor 0.23 
−2.43 VX702 p38 MAPK inhibitor 0.22 
−2.43 SB202190 p38 MAPK inhibitor 0.69 
−2.43 BEZ235 mTOR inhibitor 0.21 
−2.43 AMG-Tie2-1 Tie-2 inhibitor 4.07 
−2.43 PH-797804 p38 MAPK inhibitor 0.05 
−2.43 IKK-2 inhibitor VI  5.2 
−2.42 IKK inhibitor VII  0.28 
−2.42 GTPL6019 PDGF receptor tyrosine kinase inhibitor 12.5 
−2.42 NG25 Multiple kinase inhibitor 2.4 
−2.42 KU0063794 mTOR inhibitor 6.4 
−2.41 SB239063 p38 MAPK inhibitor 38.3 
−2.40 IKK-2 inhibitor IV  4.1 
−2.39 PI-103 mTOR inhibitor 291.7 
−2.39 GW856553X p38 MAPK inhibitor 0.06 
−2.39 SB242235 p38 MAPK inhibitor 2.2 
−2.38 SB220025 p38 MAPK inhibitor 11.5 
Z-scoreCompoundMechanismIC50 (μM)
−2.52 Cycloheximide Protein synthesis inhibitor 0.16 
−2.51 INK-128 mTOR inhibitor 0.04 
−2.51 K-252a PKA/C/G inhibitor 2.63 
−2.51 PDGF receptor tyrosine kinase inhibitor III  6.71 
−2.50 Anisomycin Protein synthesis inhibitor 0.06 
−2.49 Lycorine Protein synthesis inhibitor 3.86 
−2.48 5z-7-oxozeaenol TAK1 inhibitor 0.09 
−2.47 NVP-BHG712 EPHB4 inhibitor 1.3 
−2.47 DCC-2036 Bcr-Abl kinase/TIE/VEGF receptor inhibitor 2.0 
−2.47 GDC-0980 mTOR inhibitor 2.2 
−2.47 p38 MAPK inhibitor VIII p38 MAPK inhibitor 0.06 
−2.46 PD 169316 p38 MAPK inhibitor 0.31 
−2.46 BX795 TBK1/PDK1 inhibitor 2.3 
−2.45 PI-3Kα inhibitor IV mTOR inhibitor 3.95 
−2.45 RWJ-67657 p38 MAPK inhibitor 0.07 
−2.45 OTSSP167 MELK inhibitor 0.05 
−2.45 GNE-493 mTOR inhibitor 1.06 
−2.45 LY2228820 p38 MAPK inhibitor 0.05 
−2.44 Emetine Protein synthesis inhibitor 0.03 
−2.44 IKK-2 inhibitor XI  26.9 
−2.44 AV951 VEGF receptor inhibitor 166.3 
−2.44 SB203580 p38 MAPK inhibitor 2.4 
−2.44 KW-2449 FLT3 inhibitor 63.7 
−2.44 AMG-47a LCK inhibitor 0.23 
−2.43 VX702 p38 MAPK inhibitor 0.22 
−2.43 SB202190 p38 MAPK inhibitor 0.69 
−2.43 BEZ235 mTOR inhibitor 0.21 
−2.43 AMG-Tie2-1 Tie-2 inhibitor 4.07 
−2.43 PH-797804 p38 MAPK inhibitor 0.05 
−2.43 IKK-2 inhibitor VI  5.2 
−2.42 IKK inhibitor VII  0.28 
−2.42 GTPL6019 PDGF receptor tyrosine kinase inhibitor 12.5 
−2.42 NG25 Multiple kinase inhibitor 2.4 
−2.42 KU0063794 mTOR inhibitor 6.4 
−2.41 SB239063 p38 MAPK inhibitor 38.3 
−2.40 IKK-2 inhibitor IV  4.1 
−2.39 PI-103 mTOR inhibitor 291.7 
−2.39 GW856553X p38 MAPK inhibitor 0.06 
−2.39 SB242235 p38 MAPK inhibitor 2.2 
−2.38 SB220025 p38 MAPK inhibitor 11.5 
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