Table 1. Validated small compounds that... | Rockefeller University Press

Table 1.

Validated small compounds that induce INAVA puncta

Z-score	Compound	Mechanism	EC50 (μM)
24.1	BAPTA-AM	Ca²⁺ chelator	33.2
20.2	Thimerosal	Thiol oxidizing reagent	14.7
19.4	Furoxan	ROS inducer	94.3
12.7	Geldanamycin	HSP90 inhibitor	1.2
12.6	2043 D17	Undetermined	8.8
12.6	MG132	Proteasome inhibitor	2.2
12.0	Bortezomib	Proteasome inhibitor	0.33
12.0	17-Allylamino-geldanamycin	HSP90 inhibitor	0.07
12.0	Ganetespib	HSP90 inhibitor	0.02
11.4	Fascaplysin	Cdk inhibitor	3.4
10.0	Parthenolide	Sesquiterpene lactone	49.8
9.8	Beta-lapachone	Topoisomerase inhibitor	30.4
9.7	NVP-AUY922	HSP90 inhibitor	0.07
8.8	PDK1/Akt/Flt dual pathway inhibitor		0.83
8.8	KX01	Tubulin inhibitor	0.72
8.7	AV-412	EGFR/HER2 inhibitor	50.8
8.1	Herbimycin A	Tyrosine kinase inhibitor	4.4
7.8	Radicicol	HSP90 inhibitor	0.12
7.7	Albendazole	Tubulin inhibitor	18.6
7.5	Oxibendazole	Tubulin inhibitor	25.5
7.0	NS-1619	K-channel activator	202.8
6.7	LY-83583	ROS inducer	6.8
6.6	Cytochalasin D	Actin inhibitor	10.8
5.9	Latrunculin B	Actin inhibitor	69.0
5.8	Auranofin	Mitochondrial thioredoxin reductase inhibitor	7.5
5.8	3407 J11	Undetermined	34.1
5.1	5z-7-oxozeaenol	TAK1 inhibitor	22.1
4.9	Gramicidin	Antibacterial	9.1
4.9	Z-leu3-VS	Proteasome inhibitor	42.8

Z-score	Compound	Mechanism	EC50 (μM)
24.1	BAPTA-AM	Ca²⁺ chelator	33.2
20.2	Thimerosal	Thiol oxidizing reagent	14.7
19.4	Furoxan	ROS inducer	94.3
12.7	Geldanamycin	HSP90 inhibitor	1.2
12.6	2043 D17	Undetermined	8.8
12.6	MG132	Proteasome inhibitor	2.2
12.0	Bortezomib	Proteasome inhibitor	0.33
12.0	17-Allylamino-geldanamycin	HSP90 inhibitor	0.07
12.0	Ganetespib	HSP90 inhibitor	0.02
11.4	Fascaplysin	Cdk inhibitor	3.4
10.0	Parthenolide	Sesquiterpene lactone	49.8
9.8	Beta-lapachone	Topoisomerase inhibitor	30.4
9.7	NVP-AUY922	HSP90 inhibitor	0.07
8.8	PDK1/Akt/Flt dual pathway inhibitor		0.83
8.8	KX01	Tubulin inhibitor	0.72
8.7	AV-412	EGFR/HER2 inhibitor	50.8
8.1	Herbimycin A	Tyrosine kinase inhibitor	4.4
7.8	Radicicol	HSP90 inhibitor	0.12
7.7	Albendazole	Tubulin inhibitor	18.6
7.5	Oxibendazole	Tubulin inhibitor	25.5
7.0	NS-1619	K-channel activator	202.8
6.7	LY-83583	ROS inducer	6.8
6.6	Cytochalasin D	Actin inhibitor	10.8
5.9	Latrunculin B	Actin inhibitor	69.0
5.8	Auranofin	Mitochondrial thioredoxin reductase inhibitor	7.5
5.8	3407 J11	Undetermined	34.1
5.1	5z-7-oxozeaenol	TAK1 inhibitor	22.1
4.9	Gramicidin	Antibacterial	9.1
4.9	Z-leu3-VS	Proteasome inhibitor	42.8

EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor.