| Mice . | WBC (103/µl) . | NE (103/µl) . | LY (103/µl) . | MO (103/µl) . | RBC (106/µl) . | PLT (103/µl) . | MPV (fl) . |
|---|---|---|---|---|---|---|---|
| WT (C57BL/6J) | 4.0 ± 0.9 | 0.7 ± 0.2 | 3.1 ± 0.9 | 0.1 ± 0.0 | 10.5 ± 1.2 | 1,302 ± 302 | 7.0 ± 0.6 |
| Hbb−/−; WT-BM → WT | 25.1 ± 6.7 | 2.5 ± 1.2 | 20.6 ± 5.5 | 1.9 ± 0.5 | 4.6 ± 0.4 | 1,760 ± 328.2 | 5.1 ± 0.2 |
| Hbb−/−; WT-BM → KO | 41.5 ± 5.8** | 1.6 ± 0.5 | 39.4 ± 5.1*** | 2.8 ± 0.6 | 5.7 ± 0.6* | 1,175 ± 121.3*** | 4.8 ± 0.2 |
| Hbb−/−; KO-BM → WT | 28.1 ± 10.1 | 2.2 ± 0.8 | 23.5 ± 8.2 | 2.3 ± 1.3 | 5.0 ± 0.5 | 1,271 ± 199.5** | 5.0 ± 0.1 |
| Hbb−/−; KO-BM → KO | 34.6 ± 3.2 | 2.3 ± 0.5 | 29.7 ± 2.6 | 2.6 ± 0.4 | 4.5 ± 0.5 | 1,429 ± 117.3* | 5.2 ± 0.2 |
| Mice . | WBC (103/µl) . | NE (103/µl) . | LY (103/µl) . | MO (103/µl) . | RBC (106/µl) . | PLT (103/µl) . | MPV (fl) . |
|---|---|---|---|---|---|---|---|
| WT (C57BL/6J) | 4.0 ± 0.9 | 0.7 ± 0.2 | 3.1 ± 0.9 | 0.1 ± 0.0 | 10.5 ± 1.2 | 1,302 ± 302 | 7.0 ± 0.6 |
| Hbb−/−; WT-BM → WT | 25.1 ± 6.7 | 2.5 ± 1.2 | 20.6 ± 5.5 | 1.9 ± 0.5 | 4.6 ± 0.4 | 1,760 ± 328.2 | 5.1 ± 0.2 |
| Hbb−/−; WT-BM → KO | 41.5 ± 5.8** | 1.6 ± 0.5 | 39.4 ± 5.1*** | 2.8 ± 0.6 | 5.7 ± 0.6* | 1,175 ± 121.3*** | 4.8 ± 0.2 |
| Hbb−/−; KO-BM → WT | 28.1 ± 10.1 | 2.2 ± 0.8 | 23.5 ± 8.2 | 2.3 ± 1.3 | 5.0 ± 0.5 | 1,271 ± 199.5** | 5.0 ± 0.1 |
| Hbb−/−; KO-BM → KO | 34.6 ± 3.2 | 2.3 ± 0.5 | 29.7 ± 2.6 | 2.6 ± 0.4 | 4.5 ± 0.5 | 1,429 ± 117.3* | 5.2 ± 0.2 |
Blood cells from mice were counted using HEMAVET 950 (Drew Scientific). Data represent the mean ± SD (n = 6 mice per group). WT (C57BL/6J) male mice were 8 wk old. *, P < 0.05; **, P < 0.01; ***, P < 0.001 versus Hbb−/− after ANOVA and Dunnett’s test (four Hbb−/− chimeric groups). WBC, white blood cells; NE, neutrophils; LY, lymphocytes; MO, monocytes; PLT, platelets; MPV, mean platelet volume.