| Cell | Lamin | Observed (nm) | Expected (nm) | Observed − expected (nm) | P values | No. of NPCs | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Labeled | Median | SD | Median | SD | Median | SD | Median | SD | N |
| WT | LA | 40.4 | 38.0 | 33.5 | 56.5 | 6.9 | −18.5 | 0.00 | 14,780 | |
| WT | LC | 32.8 | 35.0 | 32.1 | 49.4 | 0.7 | −14.5 | 0.37a | 0.01a | 11,459 |
| WT | LB1 | 38.1 | 36.2 | 32.1 | 56.9 | 6.0 | −20.7 | 0.00 | 15,150 | |
| WT | LB2 | 27.6 | 29.2 | 28.1 | 38.7 | −0.6 | −9.6 | 0.00 | 17,146 | |
| Lmnb1−/− | LA | 45.1 | 48.6 | 42.4 | 216.8 | 2.7 | −168.2 | 0.59a | 0.00 | 11,971 |
| Lmna−/− | LB1 | 34.9 | 34.5 | 35.8 | 297.7 | −0.8 | −263.1 | 0.00 | 9,740 | |
| Cell | Lamin | Observed (nm) | Expected (nm) | Observed − expected (nm) | P values | No. of NPCs | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Labeled | Median | SD | Median | SD | Median | SD | Median | SD | N |
| WT | LA | 40.4 | 38.0 | 33.5 | 56.5 | 6.9 | −18.5 | 0.00 | 14,780 | |
| WT | LC | 32.8 | 35.0 | 32.1 | 49.4 | 0.7 | −14.5 | 0.37a | 0.01a | 11,459 |
| WT | LB1 | 38.1 | 36.2 | 32.1 | 56.9 | 6.0 | −20.7 | 0.00 | 15,150 | |
| WT | LB2 | 27.6 | 29.2 | 28.1 | 38.7 | −0.6 | −9.6 | 0.00 | 17,146 | |
| Lmnb1 | LA | 45.1 | 48.6 | 42.4 | 216.8 | 2.7 | −168.2 | 0.59a | 0.00 | 11,971 |
| Lmna | LB1 | 34.9 | 34.5 | 35.8 | 297.7 | −0.8 | −263.1 | 0.00 | 9,740 | |
Median and SD of the observed and expected lamin fiber to NPC center to center distances, the difference between them, P values (see Materials and methods), and number of NPCs. The data in each row were collected from 10 cells. The Mann-Whitney U test and Ansari-Bradley test were used as described in Materials and methods.
aP values above the Bonferroni corrected α value of 0.05/8 tests = 0.006.
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