Table 1.
Immunologic workup of the SLP76-deficient patient
PatientNormal rangea
CBC (cells/ml × 103
WBC 12.5 5.2–11 
Neutrophils 5.6 1–8.5 
Monocytes 0.2 0.2–1 
Lymphocytes 8.2 3.4–7.6 
Eosinophils 0.01 0–0.7 
Hemoglobin (g/dl) 9.6 11–14 
Platelets 243 150–400 
Lymphocyte subsets (cells/ml × 103
T cells (CD3+7.6 2.5–5.5 
T helper cell (CD4+0.65 1.6–4 
Cytotoxic T cell (CD8+6.65 0.6–1.7 
Double negative (CD4CD8−αβ+; % of WBC) 0.4% <1% 
αβ TCR 57% 26–100% 
γδ TCR 2% 1–38% 
Regulatory T cell (CD4+CD25+FOXP3+4% >5% 
B cells (CD45+CD19+0.36 (6%) 0.05–0.3 (5–25%) 
NK (CD16+CD56+36% 6–30% 
TREC (copies per 0.5 mg DNA) 36 >400 
Serum Ig (mg/dl)  
IgA 36 38-222 
IgM 434 56-208 
IgG 1,220 590-1,430 
PatientNormal rangea
CBC (cells/ml × 103
WBC 12.5 5.2–11 
Neutrophils 5.6 1–8.5 
Monocytes 0.2 0.2–1 
Lymphocytes 8.2 3.4–7.6 
Eosinophils 0.01 0–0.7 
Hemoglobin (g/dl) 9.6 11–14 
Platelets 243 150–400 
Lymphocyte subsets (cells/ml × 103
T cells (CD3+7.6 2.5–5.5 
T helper cell (CD4+0.65 1.6–4 
Cytotoxic T cell (CD8+6.65 0.6–1.7 
Double negative (CD4CD8−αβ+; % of WBC) 0.4% <1% 
αβ TCR 57% 26–100% 
γδ TCR 2% 1–38% 
Regulatory T cell (CD4+CD25+FOXP3+4% >5% 
B cells (CD45+CD19+0.36 (6%) 0.05–0.3 (5–25%) 
NK (CD16+CD56+36% 6–30% 
TREC (copies per 0.5 mg DNA) 36 >400 
Serum Ig (mg/dl)  
IgA 36 38-222 
IgM 434 56-208 
IgG 1,220 590-1,430 

CBC, complete blood count; TREC, TCR excision circles; WBC, white blood cell.

aHealthy donors, age 1–2 yr, with percentages/counts presented as median (10th and 90th percentiles).

or Create an Account

Close Modal
Close Modal