| . | 6 mo old . | 16 mo old . | . | ||
|---|---|---|---|---|---|
| . | WT . | Metrnβ−/− . | WT . | Metrnβ−/− . | P value . |
| IVSd (mm) | 0.57 ± 0.01 | 0.72 ± 0.03# | 0.64 ± 0.01 | 0.85 ± 0.06## | *, ### |
| LVPWd (mm) | 0.59 ± 0.03 | 0.71 ± 0.02# | 0.68 ± 0.01 | 0.69 ± 0.02 | # |
| LVIDd (mm) | 4.37 ± 0.02 | 4.30 ± 0.11 | 4.41 ± 0.06 | 4.58 ± 0.12 | |
| IVSs (mm) | 0.98 ± 0.02 | 1.12 ± 0.04# | 1.06 ± 0.01 | 1.32 ± 0.04**,### | **, #### |
| LVPWs (mm) | 0.82 ± 0.03 | 0.91 ± 0.03 | 0.80 ± 0.02 | 0.84 ± 0.03 | # |
| LVIDs (mm) | 3.21 ± 0.11 | 3.30 ± 0.15 | 3.52 ± 0.05 | 3.60 ± 0.12 | * |
| EF (%) | 58.2 ± 3.7 | 53.8 ± 2.8 | 47.0 ± 0.4* | 49.4 ± 2.1 | ** |
| FS (%) | 26.5 ± 2.4 | 23.8 ± 1.7 | 20.0 ± 0.4* | 21.2 ± 1.1 | |
| EDV (mm3) | 86.4 ± 1.2 | 83.6 ± 5.2 | 88.5 ± 3.1 | 96.7 ± 5.7 | |
| ESV (mm3) | 41.76 ± 3.6 | 44.65 ± 4.7 | 51.79 ± 1.7 | 55.0 ± 4.4 | * |
| Heart rate | 337.3 ± 17.4 | 352.6 ± 17.2 | 381.3 ± 18.6 | 382.6 ± 12.0 | * |
| LVm (mg) | 89.9 ± 2.2 | 113.4 ± 6.4# | 107.1 ± 1.8 | 148.1 ± 8.6**,### | ***, #### |
| Aortic peak (m/s) | 1.02 ± 0.06 | 0.90 ± 0.03 | 0.84 ± 0.04 | 1.07 ± 0.05*## | $$ |
| VTI (cm) | 5.72 ± 0.52 | 5.00 ± 0.19 | 4.60 ± 0.23 | 5.14 ± 0.23 | |
| E peak (m/s) | 0.78 ± 0.06 | 0.91 ± 0.06 | 0.83 ± 0.01 | 0.98 ± 0.05 | # |
| Mitral deceleration (ms) | 26.7 ± 2.1 | 27.4 ± 1.6 | 23.7 ± 1.3 | 26.6 ± 1.7 | |
| Aortic diameter (mm) | 1.15 ± 0.01 | 1.23 ± 0.03 | 1.24 ± 0.01 | 1.32 ± 0.05 | *, # |
| . | 6 mo old . | 16 mo old . | . | ||
|---|---|---|---|---|---|
| . | WT . | Metrnβ−/− . | WT . | Metrnβ−/− . | P value . |
| IVSd (mm) | 0.57 ± 0.01 | 0.72 ± 0.03# | 0.64 ± 0.01 | 0.85 ± 0.06## | *, ### |
| LVPWd (mm) | 0.59 ± 0.03 | 0.71 ± 0.02# | 0.68 ± 0.01 | 0.69 ± 0.02 | # |
| LVIDd (mm) | 4.37 ± 0.02 | 4.30 ± 0.11 | 4.41 ± 0.06 | 4.58 ± 0.12 | |
| IVSs (mm) | 0.98 ± 0.02 | 1.12 ± 0.04# | 1.06 ± 0.01 | 1.32 ± 0.04**,### | **, #### |
| LVPWs (mm) | 0.82 ± 0.03 | 0.91 ± 0.03 | 0.80 ± 0.02 | 0.84 ± 0.03 | # |
| LVIDs (mm) | 3.21 ± 0.11 | 3.30 ± 0.15 | 3.52 ± 0.05 | 3.60 ± 0.12 | * |
| EF (%) | 58.2 ± 3.7 | 53.8 ± 2.8 | 47.0 ± 0.4* | 49.4 ± 2.1 | ** |
| FS (%) | 26.5 ± 2.4 | 23.8 ± 1.7 | 20.0 ± 0.4* | 21.2 ± 1.1 | |
| EDV (mm3) | 86.4 ± 1.2 | 83.6 ± 5.2 | 88.5 ± 3.1 | 96.7 ± 5.7 | |
| ESV (mm3) | 41.76 ± 3.6 | 44.65 ± 4.7 | 51.79 ± 1.7 | 55.0 ± 4.4 | * |
| Heart rate | 337.3 ± 17.4 | 352.6 ± 17.2 | 381.3 ± 18.6 | 382.6 ± 12.0 | * |
| LVm (mg) | 89.9 ± 2.2 | 113.4 ± 6.4# | 107.1 ± 1.8 | 148.1 ± 8.6**,### | ***, #### |
| Aortic peak (m/s) | 1.02 ± 0.06 | 0.90 ± 0.03 | 0.84 ± 0.04 | 1.07 ± 0.05*## | $$ |
| VTI (cm) | 5.72 ± 0.52 | 5.00 ± 0.19 | 4.60 ± 0.23 | 5.14 ± 0.23 | |
| E peak (m/s) | 0.78 ± 0.06 | 0.91 ± 0.06 | 0.83 ± 0.01 | 0.98 ± 0.05 | # |
| Mitral deceleration (ms) | 26.7 ± 2.1 | 27.4 ± 1.6 | 23.7 ± 1.3 | 26.6 ± 1.7 | |
| Aortic diameter (mm) | 1.15 ± 0.01 | 1.23 ± 0.03 | 1.24 ± 0.01 | 1.32 ± 0.05 | *, # |
All measurements are expressed as mean ± SEM; n = 5 mice/group. Data were analyzed by two-way ANOVA, where *, P < 0.05, **, P < 0.001, ***, P < 0.0001 for 16-mo-old effect; #, P < 0.05, ##, P < 0.001, ###, P < 0.0001, ####, P < 0.00001 for genotype effect; $$, P < 0.001 for interaction effect. d, after diastole; EDV, end diastolic volume; s, after systole.