Table 2.
PU.MA patient clinical laboratory information at study enrollment
Serum immunoglobulin concentrations
Iga1–2-yr normal rangesaA.II.26–9-yr normal rangesaB.II.2E.II.1Adult normal rangesaC.II.1D.II.1F.II.1
IgA mg/dl 14–106 <6↓ 70–393 <5↓ <5↓ 70–312 <6↓ <6↓ <6↓ 
IgG mg/dl 294–1,069 <7↓ 583–1,783 On replacement On replacement 639–1,349 On replacement On replacement On replacement 
IgM mg/dl 43–173 6↓ 50–198 <5↓ <5↓ 56–352 <7↓ <7↓ <7↓ 
Cell subset number and percentage 
Subset 1–2-yr normal rangesa A.II.2 6–9-yr normal rangesa B.II.2 E.II.1 Adult normal rangesa C.II.1 D.II.1 F.II.1 
Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % 
CD3+,b 2,100–6,200 53–75 5,006 65 700–4,200 55–90 1,600 82.2 3,536 94↑ 700–2,100 55–83 400↓ 91 1,225 90 1,533 90 
CD4+/CD3+,b 1,300–3,400 32–51 2,557 33 300–2,000 27–53 490 39 1,715 52 300–1,400 28–57 194↓ 44 739 54 713 42 
CD8+/CD3+,b 620–2,000 14–30 2,325↑ 30 300–1,800 19–34 640 44↑ 1,449 41 200–900 10–39 202↓ 46 408 30 783 46 
CD19+,b 600–2,700 15–39 11↓ 0.2↓ 200–1,600 10–31 0↓ 0↓ 0↓ 0↓ 100–500 6–19 0↓ 0↓ 0.1↓ 0.03↓ 0.4↓ 0.04↓ 
CD16+CD56+ 200–1,200 3–17 393 3 90–900 4–26 230 15.5 90 2.4↓ 70–312 5–28 53↓ 12 136 10 170 10 
Monocytec 250–1,150 4.4–13.4 710 9 190–850 4.2–12.3 1,008 13.7 1,190↑ 15.9↑ 170–930 4.4–12.3 231 23 537 11 650 19 
Eosinophilc 20–820 0–3.7 560 4.5↑ 30–520 0–4.7 0↓ 0 30 0.3 30–440 0–4.4 200 7.4↑ 180 4 510 3 
Neutrophilc 1,190–7,210 17.5–69.5 3,970 32 1,630–7,550 28.6–74.5 5,620 71 4,550 60.8 1,820–7,420 40.3–74.8 1,709↓ 63 3,000 62 12,120 78 
Basophilc 10–60 0–0.6 20 0.2 10–60 0–0.7 0 0 10 0.1 10–50 0–0.7 2.7↓ 0.1↓ 10 0 30 0 
Serum immunoglobulin concentrations
Iga1–2-yr normal rangesaA.II.26–9-yr normal rangesaB.II.2E.II.1Adult normal rangesaC.II.1D.II.1F.II.1
IgA mg/dl 14–106 <6↓ 70–393 <5↓ <5↓ 70–312 <6↓ <6↓ <6↓ 
IgG mg/dl 294–1,069 <7↓ 583–1,783 On replacement On replacement 639–1,349 On replacement On replacement On replacement 
IgM mg/dl 43–173 6↓ 50–198 <5↓ <5↓ 56–352 <7↓ <7↓ <7↓ 
Cell subset number and percentage 
Subset 1–2-yr normal rangesa A.II.2 6–9-yr normal rangesa B.II.2 E.II.1 Adult normal rangesa C.II.1 D.II.1 F.II.1 
Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % Cells/μl % 
CD3+,b 2,100–6,200 53–75 5,006 65 700–4,200 55–90 1,600 82.2 3,536 94↑ 700–2,100 55–83 400↓ 91 1,225 90 1,533 90 
CD4+/CD3+,b 1,300–3,400 32–51 2,557 33 300–2,000 27–53 490 39 1,715 52 300–1,400 28–57 194↓ 44 739 54 713 42 
CD8+/CD3+,b 620–2,000 14–30 2,325↑ 30 300–1,800 19–34 640 44↑ 1,449 41 200–900 10–39 202↓ 46 408 30 783 46 
CD19+,b 600–2,700 15–39 11↓ 0.2↓ 200–1,600 10–31 0↓ 0↓ 0↓ 0↓ 100–500 6–19 0↓ 0↓ 0.1↓ 0.03↓ 0.4↓ 0.04↓ 
CD16+CD56+ 200–1,200 3–17 393 3 90–900 4–26 230 15.5 90 2.4↓ 70–312 5–28 53↓ 12 136 10 170 10 
Monocytec 250–1,150 4.4–13.4 710 9 190–850 4.2–12.3 1,008 13.7 1,190↑ 15.9↑ 170–930 4.4–12.3 231 23 537 11 650 19 
Eosinophilc 20–820 0–3.7 560 4.5↑ 30–520 0–4.7 0↓ 0 30 0.3 30–440 0–4.4 200 7.4↑ 180 4 510 3 
Neutrophilc 1,190–7,210 17.5–69.5 3,970 32 1,630–7,550 28.6–74.5 5,620 71 4,550 60.8 1,820–7,420 40.3–74.8 1,709↓ 63 3,000 62 12,120 78 
Basophilc 10–60 0–0.6 20 0.2 10–60 0–0.7 0 0 10 0.1 10–50 0–0.7 2.7↓ 0.1↓ 10 0 30 0 
a

Institutional age-based normal ranges.

b

Per total lymphocytes.

c

Per total leukocytes.

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