Table 1.
Ongoing and completed National Institutes of Health–registered clinical trials investigating EVP-based therapeutics
DiseasePhaseCellular sourceRoute of administrationIsolation methodModificationStatusReference
Melanoma Monocyte-derived DCs SC UF/UC sucrose cushion Melanoma antigen loaded Completed Escudier et al., 2005  
NSCLC Monocyte-derived DCs SC and intradermal UF/UC sucrose cushion Peptide loaded Completed Morse et al., 2005  
NSCLC Monocyte-derived DCs Intradermal UF/UC sucrose cushion Peptide loaded Completed Besse et al., 2016  
Cutaneous wound healing (ulcer) Autologous plasma-derived exosomes Intradermal 0.02-μm filter None Open NCT02565264 
SARS-CoV-2 1/2 T cells Aerosol inhalation Not specified COVID-19–specific T cells Open NCT04389385 
DiseasePhaseCellular sourceRoute of administrationIsolation methodModificationStatusReference
Melanoma Monocyte-derived DCs SC UF/UC sucrose cushion Melanoma antigen loaded Completed Escudier et al., 2005  
NSCLC Monocyte-derived DCs SC and intradermal UF/UC sucrose cushion Peptide loaded Completed Morse et al., 2005  
NSCLC Monocyte-derived DCs Intradermal UF/UC sucrose cushion Peptide loaded Completed Besse et al., 2016  
Cutaneous wound healing (ulcer) Autologous plasma-derived exosomes Intradermal 0.02-μm filter None Open NCT02565264 
SARS-CoV-2 1/2 T cells Aerosol inhalation Not specified COVID-19–specific T cells Open NCT04389385 

COVID-19; coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SC, subcutaneous; UC, ultracentrifugation; UF, ultrafiltration.

or Create an Account

Close Modal
Close Modal