Table 2. Summary of results from studies... | Rockefeller University Press

Table 2.

Summary of results from studies looking at effects of microbiome depletion or inflammatory signaling pathway deletion on numbers of cells in the HSPC compartment

HSPC definition	Intervention	HSPC number	Reference
HSC
LSK CD48⁻/CD150⁺	GF mice	No effect	Lee et al., 2019
	MyD88^−/−	No effect
	MyD88^−/−	Depleted	Fiedler et al., 2013
	Ripk2^−/−	No effect	Burberry et al., 2014
	Tlr3^−/−	No effect	Lee et al., 2019
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−
	Unc93b1^−/−	No effect
LSK CD48⁻/CD150⁺/CD34⁻/Flk2⁻	Antibiotics^a	Depleted	Josefsdottir et al., 2017
LSK CD127⁻/Flk2⁻/CD34⁻	GF mice	Depleted	Iwamura et al., 2017
	Nod1^−/−	Depleted
Short-term HSC
LSK CD48⁻/CD150⁻	MyD88^−/−	No effect	Fiedler et al., 2013
	GF mice	Increased	Lee et al., 2019
LSK CD127⁻/Flk2⁻/CD34⁺	GF mice	Depleted	Iwamura et al., 2017
MPP
LSK CD48⁺/CD150⁻	GF mice	Depleted	Lee et al., 2019
	MyD88^−/−	No effect
	Unc93b1^−/−	Depleted
	Tlr3^−/−	No effect
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−
LSK CD48^+/⁻/CD150^+/⁻/CD34⁺/Flk2^+/⁻	Antibiotics^a	Depleted	Josefsdottir et al., 2017
LSK CD127⁻/Flk2⁺	GF mice	Depleted	Iwamura et al., 2017
	Nod1^−/−	Depleted
LSK CD48⁺/CD150⁺	GF mice	Depleted	Lee et al., 2019
	MyD88^−/−	Depleted
	Unc93b1^−/−	Depleted
	Tlr3^−/−	No effect
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−

HSPC definition	Intervention	HSPC number	Reference
HSC
LSK CD48⁻/CD150⁺	GF mice	No effect	Lee et al., 2019
	MyD88^−/−	No effect
	MyD88^−/−	Depleted	Fiedler et al., 2013
	Ripk2^−/−	No effect	Burberry et al., 2014
	Tlr3^−/−	No effect	Lee et al., 2019
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−
	Unc93b1^−/−	No effect
LSK CD48⁻/CD150⁺/CD34⁻/Flk2⁻	Antibiotics^a	Depleted	Josefsdottir et al., 2017
LSK CD127⁻/Flk2⁻/CD34⁻	GF mice	Depleted	Iwamura et al., 2017
	Nod1^−/−	Depleted
Short-term HSC
LSK CD48⁻/CD150⁻	MyD88^−/−	No effect	Fiedler et al., 2013
	GF mice	Increased	Lee et al., 2019
LSK CD127⁻/Flk2⁻/CD34⁺	GF mice	Depleted	Iwamura et al., 2017
MPP
LSK CD48⁺/CD150⁻	GF mice	Depleted	Lee et al., 2019
	MyD88^−/−	No effect
	Unc93b1^−/−	Depleted
	Tlr3^−/−	No effect
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−
LSK CD48^+/⁻/CD150^+/⁻/CD34⁺/Flk2^+/⁻	Antibiotics^a	Depleted	Josefsdottir et al., 2017
LSK CD127⁻/Flk2⁺	GF mice	Depleted	Iwamura et al., 2017
	Nod1^−/−	Depleted
LSK CD48⁺/CD150⁺	GF mice	Depleted	Lee et al., 2019
	MyD88^−/−	Depleted
	Unc93b1^−/−	Depleted
	Tlr3^−/−	No effect
	Tlr4^−/−
	Tlr5^−/−
	Tlr9^−/−

LSK, Lin⁻/Sca-1⁺/c-Kit⁺.

Antibiotics in drinking water: vancomycin, neomycin, ampicillin, and metronidazole.

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