Table 1.
Starvation-specific/Vps23-dependent secreted enzymes with direct or indirect functions in response to oxidative stress
GeneProteinDescription
YJR104C/SOD1 Superoxide dismutase [Cu-Zn] Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide 
YLR109W/AHP1 Peroxiredoxin Thiol-specific peroxiredoxin; preferentially reduces alkyl hydroperoxides 
YLR043C/TRX1 Thioredoxin-1 Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system that protects cells against oxidative and reductive stress 
YGR209C/TRX2 Thioredoxin-2 Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system that protects cells against oxidative and reductive stress 
YIL053W/GPP1 Glycerol-3-phosphate phosphatase Hydrolyzes glycerol-3-P; involved in glycerol biosynthesis 
YKL060C/FBA1 Fructose-bisphosphate aldolase Catalyzes conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; required for glycolysis and gluconeogenesis 
YCR053W/THR4 Threonine synthase Catalyzes formation of threonine from O-phosphohomoserine 
YJR105W/ADO1 Adenosine kinase Required for the utilization of S-adenosylmethionine 
YGL253W/HXK2 Hexokinase-2 Phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose 
YCL050C/APA1 AP4A phosphorylase Catalyzes phosphorolysis of dinucleoside oligophosphates 
YGR234W/YHB1 Nitric oxide oxidoreductase Flavohemoglobin that plays a role in oxidative and nitrosative stress responses 
YHR163W/SOL3 6-phospho-gluconolactonase Catalyzes the second step of the pentose phosphate pathway 
YAR015W/ADE1 Adenylosuccinate synthetase Required for “de novo” purine nucleotide biosynthesis 
YJR070C/LIA1 Deoxyhypusine hydroxylase Metalloenzyme that catalyzes hypusine formation 
YDR071C/PAA1 Polyamine acetyltransferase Acetylates polyamines 
GeneProteinDescription
YJR104C/SOD1 Superoxide dismutase [Cu-Zn] Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide 
YLR109W/AHP1 Peroxiredoxin Thiol-specific peroxiredoxin; preferentially reduces alkyl hydroperoxides 
YLR043C/TRX1 Thioredoxin-1 Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system that protects cells against oxidative and reductive stress 
YGR209C/TRX2 Thioredoxin-2 Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system that protects cells against oxidative and reductive stress 
YIL053W/GPP1 Glycerol-3-phosphate phosphatase Hydrolyzes glycerol-3-P; involved in glycerol biosynthesis 
YKL060C/FBA1 Fructose-bisphosphate aldolase Catalyzes conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; required for glycolysis and gluconeogenesis 
YCR053W/THR4 Threonine synthase Catalyzes formation of threonine from O-phosphohomoserine 
YJR105W/ADO1 Adenosine kinase Required for the utilization of S-adenosylmethionine 
YGL253W/HXK2 Hexokinase-2 Phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose 
YCL050C/APA1 AP4A phosphorylase Catalyzes phosphorolysis of dinucleoside oligophosphates 
YGR234W/YHB1 Nitric oxide oxidoreductase Flavohemoglobin that plays a role in oxidative and nitrosative stress responses 
YHR163W/SOL3 6-phospho-gluconolactonase Catalyzes the second step of the pentose phosphate pathway 
YAR015W/ADE1 Adenylosuccinate synthetase Required for “de novo” purine nucleotide biosynthesis 
YJR070C/LIA1 Deoxyhypusine hydroxylase Metalloenzyme that catalyzes hypusine formation 
YDR071C/PAA1 Polyamine acetyltransferase Acetylates polyamines 

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