Table 1. Nomenclature of IL-6 family... | Rockefeller University Press

Table 1.

Nomenclature of IL-6 family cytokines and their functions

Approved symbol (ligand)	Approved name	Gene symbol (alias)	Cellular expression	Function	Approved symbol (receptor)	Approved name	Gene symbol (alias)	Cellular expression
IL6	IL-6	IL-6, BSF2, HGF, HSF	Macrophage, DC, lymphocyte, epithelial cell, osteoclast, hepatocyte	Acute responses, angiogenesis, osteoclastogenesis, differentiation of Th17 subset and B cell, glucose metabolism	IL6R	IL-6 receptor	CD126	Macrophage, monocyte, DC, hepatocyte, adipocyte
					IL6ST	IL-6 signal transducer	GP130, CD130, sGP130	Ubiquitous expression
IL11	IL=11	IL-11, AGIF	Stromal cell line, fibroblast, chondrocytes, various cancers	Hematopoiesis, adipogenesis, neuronal differentiation, bone metabolism, cell proliferation, invasiveness	IL11RA	IL-11 receptor subunit α		Various cancers
OSM	Oncostatin M	MGC20461	Monocyte, macrophage, neutrophil, T cell	Hematopoiesis, bone turnover, lipid metabolism, liver regeneration	OSMR	Oncostatin M receptor	OSMRB, OSMRβ	Nonhematopoietic cell; hepatocyte, epithelial cell, endothelial cell, stromal cell, fibroblast cell
LIF	Leukemia inhibitory factor	CDF, DIA, HILDA	T cell, activated monocyte, fibroblast, endothelial cell	Bone remodeling, neural regeneration,	LIFR	LIF receptor subunit alpha	CD118	skeletal muscle cell, cardiomyocyte
CTF1	Cardiotrophin 1	CT-1, CT1	Cardiac myocyte	Apoptosis
CNTF	Ciliary neurotrophic factor	HCNTF	Osteoblast, osteocyte, osteoclast, chondrocyte	Bone metabolism, glucose metabolism	CNTFR	Ciliary neurotrophic factor receptor		Skeletal muscle cell
CLCF1	Cardiotrophin-like cytokine factor 1	NNT1, BSF3, CLC, NR6, CISS2, BSF-3, NNT-1	Activated Jurkat human T cell lymphoma cell	Development of nervous system
IL27	IL-27	IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873	Antigen-presenting cell	Differentiation of T cell subsets	IL27RA	IL-27 receptor subunit α	WSX-1, CCR, CRL1, WSX1, zcytor1, IL-27R	Macrophage, DC, T cell, B cell
EBI3	Epstein-Barr virus–induced 3	IL27B, IL35B	B cell
IL12A	IL-12A	CLMF, IL-12A, p35, NFSK	Macrophage, DC, neutrophil	Differentiation of Th1, Th2 subset	IL12RB	IL-12 receptor subunit β	CD212	T cell, NK cell
IL23A	IL-23 subunit α	SGRF, IL23P19, IL-23, IL-23A, p19			IL23R	IL-23 receptor	IL-23R

Approved symbol (ligand)	Approved name	Gene symbol (alias)	Cellular expression	Function	Approved symbol (receptor)	Approved name	Gene symbol (alias)	Cellular expression
IL6	IL-6	IL-6, BSF2, HGF, HSF	Macrophage, DC, lymphocyte, epithelial cell, osteoclast, hepatocyte	Acute responses, angiogenesis, osteoclastogenesis, differentiation of Th17 subset and B cell, glucose metabolism	IL6R	IL-6 receptor	CD126	Macrophage, monocyte, DC, hepatocyte, adipocyte
					IL6ST	IL-6 signal transducer	GP130, CD130, sGP130	Ubiquitous expression
IL11	IL=11	IL-11, AGIF	Stromal cell line, fibroblast, chondrocytes, various cancers	Hematopoiesis, adipogenesis, neuronal differentiation, bone metabolism, cell proliferation, invasiveness	IL11RA	IL-11 receptor subunit α		Various cancers
OSM	Oncostatin M	MGC20461	Monocyte, macrophage, neutrophil, T cell	Hematopoiesis, bone turnover, lipid metabolism, liver regeneration	OSMR	Oncostatin M receptor	OSMRB, OSMRβ	Nonhematopoietic cell; hepatocyte, epithelial cell, endothelial cell, stromal cell, fibroblast cell
LIF	Leukemia inhibitory factor	CDF, DIA, HILDA	T cell, activated monocyte, fibroblast, endothelial cell	Bone remodeling, neural regeneration,	LIFR	LIF receptor subunit alpha	CD118	skeletal muscle cell, cardiomyocyte
CTF1	Cardiotrophin 1	CT-1, CT1	Cardiac myocyte	Apoptosis
CNTF	Ciliary neurotrophic factor	HCNTF	Osteoblast, osteocyte, osteoclast, chondrocyte	Bone metabolism, glucose metabolism	CNTFR	Ciliary neurotrophic factor receptor		Skeletal muscle cell
CLCF1	Cardiotrophin-like cytokine factor 1	NNT1, BSF3, CLC, NR6, CISS2, BSF-3, NNT-1	Activated Jurkat human T cell lymphoma cell	Development of nervous system
IL27	IL-27	IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873	Antigen-presenting cell	Differentiation of T cell subsets	IL27RA	IL-27 receptor subunit α	WSX-1, CCR, CRL1, WSX1, zcytor1, IL-27R	Macrophage, DC, T cell, B cell
EBI3	Epstein-Barr virus–induced 3	IL27B, IL35B	B cell
IL12A	IL-12A	CLMF, IL-12A, p35, NFSK	Macrophage, DC, neutrophil	Differentiation of Th1, Th2 subset	IL12RB	IL-12 receptor subunit β	CD212	T cell, NK cell
IL23A	IL-23 subunit α	SGRF, IL23P19, IL-23, IL-23A, p19			IL23R	IL-23 receptor	IL-23R

DC, dendritic cell; NK, natural killer.