Table 1. Summary of the correlation of... | Rockefeller University Press

Table 1.

Summary of the correlation of expression of several endothelial- and epithelial-specific factors with physiological markers of COPD (% FEV₁, % DLCO, and % emphysema)

	% FEV₁ adjusted for age, sex, library		% DLCO adjusted for age, sex, library		% Emphysema adjusted for age, sex, library
	R²	P value^a	R²	P value^a	R²	P value^a
Endothelial markers
KDR	0.11	5.5 × 10⁻⁹	0.136	1.01 × 10⁻¹⁰	0.078	4.74 × 10⁻⁵
VEGFA	0.09	4.7 × 10⁻⁹	0.152	3.9 × 10⁻¹²	0.014	0.035
ICAM2	0.022	0.0031	0.06	6.17 × 10⁻⁶	0.009	0.08
TEK	0.019	0.013	0.06	2.46 × 10⁻⁵	0.01	0.023
TIE1	0.047	5.7 × 10⁻⁶	0.095	1.7 × 10⁻⁸	0.051	5.8 × 10⁻⁵
Epithelial cell markers
CDH1	0.007	0.1	0.018	0.0167	0.0016	0.24
SFTPD	2.12 × 10⁻⁶	0.8	0.023	0.0049	0.0018	0.346
AQP5	0.011	0.02	1.6 × 10⁻⁵	0.97	0.0027	0.153
SFTPC	0.0078	0.149	0.03	0.003	0.0045	0.3

	% FEV₁ adjusted for age, sex, library		% DLCO adjusted for age, sex, library		% Emphysema adjusted for age, sex, library
	R²	P valuea	R²	P valuea	R²	P valuea
Endothelial markers
KDR	0.11	5.5 × 10⁻⁹	0.136	1.01 × 10⁻¹⁰	0.078	4.74 × 10⁻⁵
VEGFA	0.09	4.7 × 10⁻⁹	0.152	3.9 × 10⁻¹²	0.014	0.035
ICAM2	0.022	0.0031	0.06	6.17 × 10⁻⁶	0.009	0.08
TEK	0.019	0.013	0.06	2.46 × 10⁻⁵	0.01	0.023
TIE1	0.047	5.7 × 10⁻⁶	0.095	1.7 × 10⁻⁸	0.051	5.8 × 10⁻⁵
Epithelial cell markers
CDH1	0.007	0.1	0.018	0.0167	0.0016	0.24
SFTPD	2.12 × 10⁻⁶	0.8	0.023	0.0049	0.0018	0.346
AQP5	0.011	0.02	1.6 × 10⁻⁵	0.97	0.0027	0.153
SFTPC	0.0078	0.149	0.03	0.003	0.0045	0.3

Generalized linear model Wald statistics were used to assess the significance of coefficients in relevant models.

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