Table 1.
Luminal membrane permeability assignment for Na+ and K+ permeabilities
CNTeCNTas
Na+K+Na+K+
Control     
Whole-cell current (pA/cell) 660 −430 30 −260 
Luminal fluxes (fmol/cell) 6.8 −4.5 0.3 −2.7 
Epithelial fluxes (nmol/s/cm2)a 6.1 −3.9 0.3 −2.4 
HMI0 (cm3/s/cm2 epithelium) × 105 16.5 2.8 0.13 1.8 
High-K diet     
Whole-cell current (pA/cell) 770 −1,250 480 −780 
Luminal fluxes (fmol/cell) 8.0 −13.0 5.0 −8.1 
Epithelial fluxes (nmol/s/cm2)a 7.1 −11.5 4.4 −7.2 
HMI0 (cm3/s/cm2 epithelium) × 105 24.9 8.5 2.2 5.3 
Low-K diet     
Whole-cell current (pA/cell) 360 −180   
Luminal fluxes (fmol/cell) 3.7 −1.9   
Epithelial fluxes (nmol/s/cm2)a 3.3 −1.7   
HMI0 (cm3/s/cm2 epithelium) × 105 8.5 1.2 0.13 1.8 

Assumes 500 cells/mm of tubule and tubular inner diameter of 18 µm.

a

Transcellular fluxes refer to epithelial area.

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