Table 2.
Force transients in intact PMs from the hearts of RCM-E143K versus WT-ELC mice
ParameterWTHCM-A57GΔ43RCM-E143K
Number of animals 11 (7 M, 4 F) 8 (5 M, 3 F) 6 (3 M, 3 F) 8 (3 M, 5 F) 
t25 relax (ms) 57.2 ± 7.7 48.6 ± 5.2a 61.8 ± 5.3b 69.3 ± 7.4a,c 
t50 relax (ms) 92.6 ± 11.5 78.1 ± 8.6a 98.8 ± 11.0b 111.8 ± 13.9a,c 
t75 relax (ms) 136.5 ± 16.0 115.8 ± 17.3 148.3 ± 17.90b 166.8 ± 21.0a,c 
Force/area (mN/mm20.42 ± 0.27 0.34 ± 0.23 0.24 ± 0.13 0.39 ± 0.16 
ParameterWTHCM-A57GΔ43RCM-E143K
Number of animals 11 (7 M, 4 F) 8 (5 M, 3 F) 6 (3 M, 3 F) 8 (3 M, 5 F) 
t25 relax (ms) 57.2 ± 7.7 48.6 ± 5.2a 61.8 ± 5.3b 69.3 ± 7.4a,c 
t50 relax (ms) 92.6 ± 11.5 78.1 ± 8.6a 98.8 ± 11.0b 111.8 ± 13.9a,c 
t75 relax (ms) 136.5 ± 16.0 115.8 ± 17.3 148.3 ± 17.90b 166.8 ± 21.0a,c 
Force/area (mN/mm20.42 ± 0.27 0.34 ± 0.23 0.24 ± 0.13 0.39 ± 0.16 

Data are mean ± SD. P values were calculated with one-way ANOVA with Tukey’s multiple comparison test. For comparisons between the RCM, HCM, and Δ43 phenotypes, the data for HCM-A57G and Δ43 animals (columns 3 and 4) were taken, with permission, from Sitbon et al. (2020).

a

P < 0.05 for mutant versus WT-ELC.

b

P < 0.05 for Δ43 versus A57G.

c

P < 0.05 for E143K versus A57G.

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