| Channel . | BTXresistant? . | Activation shift? ΔV1/2 act(mV) . | Inactivation shift? ΔV1/2 inact(mV) . | Decrease in current density? (fold change) . |
|---|---|---|---|---|
| Pum NaV1.4 N432T (DI) | No | No | No | No |
| Pum NaV1.4 N830T (DII) | No | No | Yes; −10.8 ± 1.6 | Yes; 14.8 |
| Pum NaV1.4 N1306T (DIII) | No | No | No | No |
| Pum NaV1.4 N1609T (DIV) | Yes | Yes; +20.5 ± 1.5 | Yes; −10.3 ± 2.1 | Yes; 4.9 |
| Pum NaV1.4 N1609A (DIV) | No | Yes; +19.6 ± 1.6 | Yes; −13.4 ± 1.6 | Yes; 4.1 |
| Hs NaV1.4 N1591T (DIV) | Yes | Yes; +16.9 ± 2.7 | Yes; −9.8 ± 1.2 | Yes; 2.2 |
| Rn NaV1.4 N1584T (DIV) | Yes | Yes; +18.0 ± 0.6 | Yes; −27.0 ± 0.4 | Yes; 10.3 |
| Pt NaV1.4 (N1600T) (DIV) | No | No | Yes; −7.7 ± 0.9 | No* |
| Dt NaV1.4 (N1600T) (DIV) | No | No | Yes; −9.8 ± 1.9 | No* |
| Channel . | BTXresistant? . | Activation shift? ΔV1/2 act(mV) . | Inactivation shift? ΔV1/2 inact(mV) . | Decrease in current density? (fold change) . |
|---|---|---|---|---|
| Pum NaV1.4 N432T (DI) | No | No | No | No |
| Pum NaV1.4 N830T (DII) | No | No | Yes; −10.8 ± 1.6 | Yes; 14.8 |
| Pum NaV1.4 N1306T (DIII) | No | No | No | No |
| Pum NaV1.4 N1609T (DIV) | Yes | Yes; +20.5 ± 1.5 | Yes; −10.3 ± 2.1 | Yes; 4.9 |
| Pum NaV1.4 N1609A (DIV) | No | Yes; +19.6 ± 1.6 | Yes; −13.4 ± 1.6 | Yes; 4.1 |
| Hs NaV1.4 N1591T (DIV) | Yes | Yes; +16.9 ± 2.7 | Yes; −9.8 ± 1.2 | Yes; 2.2 |
| Rn NaV1.4 N1584T (DIV) | Yes | Yes; +18.0 ± 0.6 | Yes; −27.0 ± 0.4 | Yes; 10.3 |
| Pt NaV1.4 (N1600T) (DIV) | No | No | Yes; −7.7 ± 0.9 | No* |
| Dt NaV1.4 (N1600T) (DIV) | No | No | Yes; −9.8 ± 1.9 | No* |
Data represent measurements in transfected HEK293 cells. *, substantial current density loss in Xenopus oocytes. ΔV1/2 act = V1/2, act mutant -V1/2, act WT. ΔV1/2 inact = V1/2, inact mutant -V1/2, inact WT.