Table 4.
Effect of amiloride analogs and NSAIDs on MEC-4d currents relative to uninjected oocytes: estimation statistics supporting Fig. 3 and Fig. 5
MEC-4dΔIdrug (µA)95% CI (µA)P
Amiloride analogs 
Amiloride 6.71 (50) (5.1 to 8.87) 2.07e-15 
Benzamil 7.81 (32) (5.43 to 11.0) 2.03e-12 
EIPA 5.53 (27) (3.77 to 8.11) 2.07e-11 
Phenamil 5.18 (26) (3.1 to 8.08) 2.02e-09 
Benzamidine 0.61 (25) (−0.065 to 1.68) 0.0022 
NSAIDs 
Ibuprofen −4.39 (9) (−6.43 to −2.69) 0.0015 
Flurbiprofen −3.7 (7) (−4.66 to −2.92) 0.0008 
Diclofenac −2.78 (24) (−4.44 to −1.66) 9.91e-08 
Aspirin −4.75 (6) (−7.73 to −3.45) 0.0014 
Salicylic acid −5.39 (7) (−7.26 to −3.89) 0.0008 
MEC-4dΔIdrug (µA)95% CI (µA)P
Amiloride analogs 
Amiloride 6.71 (50) (5.1 to 8.87) 2.07e-15 
Benzamil 7.81 (32) (5.43 to 11.0) 2.03e-12 
EIPA 5.53 (27) (3.77 to 8.11) 2.07e-11 
Phenamil 5.18 (26) (3.1 to 8.08) 2.02e-09 
Benzamidine 0.61 (25) (−0.065 to 1.68) 0.0022 
NSAIDs 
Ibuprofen −4.39 (9) (−6.43 to −2.69) 0.0015 
Flurbiprofen −3.7 (7) (−4.66 to −2.92) 0.0008 
Diclofenac −2.78 (24) (−4.44 to −1.66) 9.91e-08 
Aspirin −4.75 (6) (−7.73 to −3.45) 0.0014 
Salicylic acid −5.39 (7) (−7.26 to −3.89) 0.0008 

Estimation statistics for Fig. 3 G and Fig. 5 G are described as a change in current (ΔIdrug) compared to uninjected oocytes, the 95% CI (in µA), and a two-sided P value of the Mann–Whitney test. Numbers of experiments are given in parentheses (n).

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