Table 3.
Effect of amiloride analogs and NSAIDs on UNC-8d currents relative to uninjected oocytes: estimation statistics supporting Fig. 3 and Fig. 5
UNC-8dΔIdrug (μA)95% CI (µA)P
Amiloride analogs 
Amiloride 0.22 (5) (0.026 to 0.29) 0.03 
Benzamil 0.87 (18) (0.64 to 1.13) 2.08e-09 
EIPA 0.61 (9) (0.45 to 0.83) 4.92e-06 
Phenamil 0.18 (10) (0.12 to 0.26) 2.86e-06 
Benzamidine 0.32 (9) (0.17 to 0.58) 1.29e-05 
NSAIDs 
Ibuprofen 0.026 (15) (0.000518 to 0.0492) 0.024 
Flurbiprofen 0.22 (10) (0.123 to 0.382) 0.00033 
Diclofenac 0.24 (13) (0.156 to 0.352) 5.25e-06 
Aspirin −0.071 (9) (−0.162 to 0.00864) 0.39 
Salicylic acid −0.062 (10) (−0.197 to 0.00931) 0.16 
UNC-8dΔIdrug (μA)95% CI (µA)P
Amiloride analogs 
Amiloride 0.22 (5) (0.026 to 0.29) 0.03 
Benzamil 0.87 (18) (0.64 to 1.13) 2.08e-09 
EIPA 0.61 (9) (0.45 to 0.83) 4.92e-06 
Phenamil 0.18 (10) (0.12 to 0.26) 2.86e-06 
Benzamidine 0.32 (9) (0.17 to 0.58) 1.29e-05 
NSAIDs 
Ibuprofen 0.026 (15) (0.000518 to 0.0492) 0.024 
Flurbiprofen 0.22 (10) (0.123 to 0.382) 0.00033 
Diclofenac 0.24 (13) (0.156 to 0.352) 5.25e-06 
Aspirin −0.071 (9) (−0.162 to 0.00864) 0.39 
Salicylic acid −0.062 (10) (−0.197 to 0.00931) 0.16 

Estimation statistics for Fig. 3 F and Fig. 5 F are described as a change in current (ΔIdrug) compared to uninjected oocytes, the 95% CI (in µA), and a two-sided P value of the Mann–Whitney test. Numbers of experiments are given in parentheses (n).

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