Table 2.
Effect of amiloride analogs and NSAIDs on DEGT-1d currents relative to uninjected oocytes: estimation statistics supporting Fig. 3 and Fig. 5
DEGT-1dΔIdrug (µA)95% CI (µA)P
Amiloride analogs 
Amiloride 0.0033 (20) (−0.02 to 0.025) 0.36 
Benzamil 0.0073 (18) (−0.009 to 0.035) 0.61 
EIPA 0.0073 (13) (−0.008 to 0.028) 0.43 
Phenamil −0.0043 (13) (−0.024 to 0.016) 0.32 
Benzamidine 0.0041(13) (−0.012 to 0.026) 0.77 
NSAIDs 
Ibuprofen 0.02 (18) (0.0068 to 0.036) 0.001 
Flurbiprofen 0.15 (5) (0.084 to 0.22) 0.003 
Diclofenac −0.037 (5) (−0.075 to −0.015) 0.003 
Aspirin 0.037 (5) (0.0075 to 0.064) 0.08 
Salicylic acid 0.073 (4) (0.042 to 0.094) 0.006 
DEGT-1dΔIdrug (µA)95% CI (µA)P
Amiloride analogs 
Amiloride 0.0033 (20) (−0.02 to 0.025) 0.36 
Benzamil 0.0073 (18) (−0.009 to 0.035) 0.61 
EIPA 0.0073 (13) (−0.008 to 0.028) 0.43 
Phenamil −0.0043 (13) (−0.024 to 0.016) 0.32 
Benzamidine 0.0041(13) (−0.012 to 0.026) 0.77 
NSAIDs 
Ibuprofen 0.02 (18) (0.0068 to 0.036) 0.001 
Flurbiprofen 0.15 (5) (0.084 to 0.22) 0.003 
Diclofenac −0.037 (5) (−0.075 to −0.015) 0.003 
Aspirin 0.037 (5) (0.0075 to 0.064) 0.08 
Salicylic acid 0.073 (4) (0.042 to 0.094) 0.006 

Estimation statistics for Fig. 3 E and Fig. 5 E are described as a change in current (ΔIdrug) compared to uninjected oocytes, the 95% CI (in µA), and a two-sided P value of the Mann–Whitney test. Numbers of experiments are given in parentheses (n).

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