| Control | ML277 | ||||||
|---|---|---|---|---|---|---|---|
| Mean ± SEM | No. of cells | Active/total | Mean ± SEM | No. of cells | Active/total | P value | |
| EQ | 1.44 ± 0.09 | 7 | 123/587 | 1.16 ± 0.09 | 6 | 116/835 | P = 0.006 |
| EQQ | 1.12 ± 0.07 | 5 | 138/356 | 0.54 ± 0.03 | 4 | 347/602 | P < 0.0001 |
| EQQQQ | 0.91 ± 0.07 | 3 | 108/287 | 0.64 ± 0.04 | 3 | 223/703 | P < 0.0001 |
| Control | ML277 | ||||||
|---|---|---|---|---|---|---|---|
| Mean ± SEM | No. of cells | Active/total | Mean ± SEM | No. of cells | Active/total | P value | |
| 1.44 ± 0.09 | 7 | 123/587 | 1.16 ± 0.09 | 6 | 116/835 | P = 0.006 | |
| 1.12 ± 0.07 | 5 | 138/356 | 0.54 ± 0.03 | 4 | 347/602 | P < 0.0001 | |
| 0.91 ± 0.07 | 3 | 108/287 | 0.64 ± 0.04 | 3 | 223/703 | P < 0.0001 | |
First latencies were obtained from 4-s sweeps pulsed to +60 mV. Only active sweeps were used for averages. Statistical comparison was performed using a Mann–Whitney test in GraphPad Prism.
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