Table 3.
First latency to channel opening for EQ, EQQ, and EQQQQ before and after ML277 treatment
ControlML277
Mean ± SEMNo. of cellsActive/totalMean ± SEMNo. of cellsActive/totalP value
EQ 1.44 ± 0.09 123/587 1.16 ± 0.09 116/835 P = 0.006 
EQQ 1.12 ± 0.07 138/356 0.54 ± 0.03 347/602 P < 0.0001 
EQQQQ 0.91 ± 0.07 108/287 0.64 ± 0.04 223/703 P < 0.0001 
ControlML277
Mean ± SEMNo. of cellsActive/totalMean ± SEMNo. of cellsActive/totalP value
EQ 1.44 ± 0.09 123/587 1.16 ± 0.09 116/835 P = 0.006 
EQQ 1.12 ± 0.07 138/356 0.54 ± 0.03 347/602 P < 0.0001 
EQQQQ 0.91 ± 0.07 108/287 0.64 ± 0.04 223/703 P < 0.0001 

First latencies were obtained from 4-s sweeps pulsed to +60 mV. Only active sweeps were used for averages. Statistical comparison was performed using a Mann–Whitney test in GraphPad Prism.

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