Table 2.
Initial conditions for simulations of liposomal-flux assays
Parameter (unit)MeaningEstimated values
Hint (M) Interior [H] (constant) 10−6.5 (pH = 6.5) 
Hext (M) Exterior [H] (constant) 10−7.5 (pH = 7.5) 
Dint (M) Initial internal [drug] 25 × 10−9 
Dext (M) Initial external [drug] 25 × 10−9 
Parameter (unit)MeaningEstimated values
Hint (M) Interior [H] (constant) 10−6.5 (pH = 6.5) 
Hext (M) Exterior [H] (constant) 10−7.5 (pH = 7.5) 
Dint (M) Initial internal [drug] 25 × 10−9 
Dext (M) Initial external [drug] 25 × 10−9 

Due to the fully reversible system, initial conditions of EmrE species do not impact final steady-state drug concentration (Tr; Craciun and Feinberg, 2006).

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