Table 1.
PK results following oral 25-mg alpelisib in the two infants
TimeAlpelisib concentration (ng/ml)BZG791 concentration (ng/ml)
Patient 1    
First dose 3 h after dose 96.1 3.26 
Steady-state 0 h before dose (Ctrough, ss) 188 6.82 
Steady-state 3 h after dose (Cmax, ss) 543 11.6 
Patient 2    
First dose 3 h after dose 240 11.9 
Steady-state 0 h before dose (Ctrough, ss) 85.5 4.88 
Steady-state 3 h after dose (Cmax, ss) 835 28.8 
TimeAlpelisib concentration (ng/ml)BZG791 concentration (ng/ml)
Patient 1    
First dose 3 h after dose 96.1 3.26 
Steady-state 0 h before dose (Ctrough, ss) 188 6.82 
Steady-state 3 h after dose (Cmax, ss) 543 11.6 
Patient 2    
First dose 3 h after dose 240 11.9 
Steady-state 0 h before dose (Ctrough, ss) 85.5 4.88 
Steady-state 3 h after dose (Cmax, ss) 835 28.8 

Ctrough, concentration reached by a drug immediately before the next dose is administered; ss, steady-state.

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