Table 4. Comparison of SARS-CoV-2 MA... | Rockefeller University Press

Table 4.

Comparison of SARS-CoV-2 MA virus lung titers with either single hu-mAb or hu-mAb combination prophylaxis

Antibody ID	C121-LS	C135-LS	C144-LS	C135-LS+C121-LS			C135-LS+C144-LS			Isotype control
Dose level (mg/kg)	8	8	8	16	5.3	1.8	16	5.3	1.8	16
Number of animals	10	9	10	15	9	10	15	10	10	14
Minimum (PFU/ml)	1.5E+02	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	3.3E+05
Maximum (PFU/ml)	7.5E+03	3.5E+03	2.0E+03	4.5E+01	6.0E+02	4.5E+05	3.0E+02	4.5E+01	1.2E+05	4.5E+06
Range	7.4E+03	3.5E+03	2.0E+03	0.0E+00	5.6E+02	4.5E+05	2.6E+02	0.0E+00	1.1E+05	4.2E+06
Geometric mean (PFU/ml)	1.1E+03	3.3E+02	1.5E+02	4.5E+01	1.2E+02	9.3E+03	5.1E+01	4.5E+01	6.9E+03	1.2E+06
Geometric SD factor	4.0	4.8	5.0	1.0	2.8	21.9	1.6	1.0	18.6	2.4

Antibody ID	C121-LS	C135-LS	C144-LS	C135-LS+C121-LS			C135-LS+C144-LS			Isotype control
Dose level (mg/kg)	8	8	8	16	5.3	1.8	16	5.3	1.8	16
Number of animals	10	9	10	15	9	10	15	10	10	14
Minimum (PFU/ml)	1.5E+02	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	4.5E+01	3.3E+05
Maximum (PFU/ml)	7.5E+03	3.5E+03	2.0E+03	4.5E+01	6.0E+02	4.5E+05	3.0E+02	4.5E+01	1.2E+05	4.5E+06
Range	7.4E+03	3.5E+03	2.0E+03	0.0E+00	5.6E+02	4.5E+05	2.6E+02	0.0E+00	1.1E+05	4.2E+06
Geometric mean (PFU/ml)	1.1E+03	3.3E+02	1.5E+02	4.5E+01	1.2E+02	9.3E+03	5.1E+01	4.5E+01	6.9E+03	1.2E+06
Geometric SD factor	4.0	4.8	5.0	1.0	2.8	21.9	1.6	1.0	18.6	2.4