Table 1. Clinical and epidemiological... | Rockefeller University Press

Table 1.

Clinical and epidemiological characteristics of the eight patients included in the study with adverse events following YFV-17D vaccination

Case no.	Auto-Abs to type I IFNs	Inborn errors of type I IFNs^a	Country of origin and residence	Sex	Age (yr)	Family history	YFV-17D disease	Vaccination year and age	Clinical and biological features	YFV-17D isolate	Other severe infectious diseases and age (yr)	Co-morbidities (age of diagnosis)	Patient
1	Negative	AR IFNAR1 deficiency	Brazil	F	16	—	YEL-AVD	2017, 12 yr	Fever, shock, renal and hepatic insufficiency, pleural effusion and atelectasis	Blood	No	None	P2, Hernandez et al., 2019
2	Negative	AR IFNAR2 deficiency	Brazil	F	35	Sister died from YEL-AVD at 19 yr	YEL-AVD	1999, 13 yr	Fever, hypotension, bleeding, hepatitis, thrombopenia	Not tested	No	None	P1, this report
3	Positive	Negative	Germany	M	62	—	YEL-AND/YEL-AVD	2016, 57 yr	Fever, meningo-encephalitis, hepatitis	Urine	Influenza B pneumonia, 59 yr	None	P2, this report
4	Positive	Negative	Brazil	F	50	—	YEL-AVD	2017, 47 yr	Fever, shock, renal insufficiency, hepatic insufficiency, thrombopenia	Blood	No	SLE (47 yr)	P3, this report
5	Positive	Negative	US	M	80	—	YEL-AVD	2004, 64 yr	Fever, shock, renal insufficiency, thrombopenia, hepatitis	Blood	No	None	P4, this report
6	Negative	Negative	Brazil	M	25	2 siblings (brother, aged 32 yr and sister, aged 32 yr) died from YEL-AVD	YEL-AVD	2018, 28 yr	Fever, nausea, vomiting, headache, hepatitis	Blood	No	None	—
7	Negative	Negative	Brazil	M	25	Father: myasthenia gravis	YEL-AND	2017, 22 yr	Fever, headache, vomiting, dizziness	CSF	No	None	—
8	Negative	Negative	Belgium	M	56	-	YEL-AND	2020, 56 yr	Fever, headache, cognitive problems	CSF	No	None	—

Case no.	Auto-Abs to type I IFNs	Inborn errors of type I IFNsa	Country of origin and residence	Sex	Age (yr)	Family history	YFV-17D disease	Vaccination year and age	Clinical and biological features	YFV-17D isolate	Other severe infectious diseases and age (yr)	Co-morbidities (age of diagnosis)	Patient
1	Negative	AR IFNAR1 deficiency	Brazil	F	16	—	YEL-AVD	2017, 12 yr	Fever, shock, renal and hepatic insufficiency, pleural effusion and atelectasis	Blood	No	None	P2, Hernandez et al., 2019
2	Negative	AR IFNAR2 deficiency	Brazil	F	35	Sister died from YEL-AVD at 19 yr	YEL-AVD	1999, 13 yr	Fever, hypotension, bleeding, hepatitis, thrombopenia	Not tested	No	None	P1, this report
3	Positive	Negative	Germany	M	62	—	YEL-AND/YEL-AVD	2016, 57 yr	Fever, meningo-encephalitis, hepatitis	Urine	Influenza B pneumonia, 59 yr	None	P2, this report
4	Positive	Negative	Brazil	F	50	—	YEL-AVD	2017, 47 yr	Fever, shock, renal insufficiency, hepatic insufficiency, thrombopenia	Blood	No	SLE (47 yr)	P3, this report
5	Positive	Negative	US	M	80	—	YEL-AVD	2004, 64 yr	Fever, shock, renal insufficiency, thrombopenia, hepatitis	Blood	No	None	P4, this report
6	Negative	Negative	Brazil	M	25	2 siblings (brother, aged 32 yr and sister, aged 32 yr) died from YEL-AVD	YEL-AVD	2018, 28 yr	Fever, nausea, vomiting, headache, hepatitis	Blood	No	None	—
7	Negative	Negative	Brazil	M	25	Father: myasthenia gravis	YEL-AND	2017, 22 yr	Fever, headache, vomiting, dizziness	CSF	No	None	—
8	Negative	Negative	Belgium	M	56	-	YEL-AND	2020, 56 yr	Fever, headache, cognitive problems	CSF	No	None	—

F, female; M, male.

Coding regions of IFNAR1, IFNAR2, TYK2, JAK1, STAT1, STAT2, and IRF9.