| Case no. . | Auto-Abs to type I IFNs . | Inborn errors of type I IFNsa . | Country of origin and residence . | Sex . | Age (yr) . | Family history . | YFV-17D disease . | Vaccination year and age . | Clinical and biological features . | YFV-17D isolate . | Other severe infectious diseases and age (yr) . | Co-morbidities (age of diagnosis) . | Patient . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Negative | AR IFNAR1 deficiency | Brazil | F | 16 | — | YEL-AVD | 2017, 12 yr | Fever, shock, renal and hepatic insufficiency, pleural effusion and atelectasis | Blood | No | None | P2, Hernandez et al., 2019 |
| 2 | Negative | AR IFNAR2 deficiency | Brazil | F | 35 | Sister died from YEL-AVD at 19 yr | YEL-AVD | 1999, 13 yr | Fever, hypotension, bleeding, hepatitis, thrombopenia | Not tested | No | None | P1, this report |
| 3 | Positive | Negative | Germany | M | 62 | — | YEL-AND/YEL-AVD | 2016, 57 yr | Fever, meningo-encephalitis, hepatitis | Urine | Influenza B pneumonia, 59 yr | None | P2, this report |
| 4 | Positive | Negative | Brazil | F | 50 | — | YEL-AVD | 2017, 47 yr | Fever, shock, renal insufficiency, hepatic insufficiency, thrombopenia | Blood | No | SLE (47 yr) | P3, this report |
| 5 | Positive | Negative | US | M | 80 | — | YEL-AVD | 2004, 64 yr | Fever, shock, renal insufficiency, thrombopenia, hepatitis | Blood | No | None | P4, this report |
| 6 | Negative | Negative | Brazil | M | 25 | 2 siblings (brother, aged 32 yr and sister, aged 32 yr) died from YEL-AVD | YEL-AVD | 2018, 28 yr | Fever, nausea, vomiting, headache, hepatitis | Blood | No | None | — |
| 7 | Negative | Negative | Brazil | M | 25 | Father: myasthenia gravis | YEL-AND | 2017, 22 yr | Fever, headache, vomiting, dizziness | CSF | No | None | — |
| 8 | Negative | Negative | Belgium | M | 56 | - | YEL-AND | 2020, 56 yr | Fever, headache, cognitive problems | CSF | No | None | — |
| Case no. . | Auto-Abs to type I IFNs . | Inborn errors of type I IFNsa . | Country of origin and residence . | Sex . | Age (yr) . | Family history . | YFV-17D disease . | Vaccination year and age . | Clinical and biological features . | YFV-17D isolate . | Other severe infectious diseases and age (yr) . | Co-morbidities (age of diagnosis) . | Patient . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Negative | AR IFNAR1 deficiency | Brazil | F | 16 | — | YEL-AVD | 2017, 12 yr | Fever, shock, renal and hepatic insufficiency, pleural effusion and atelectasis | Blood | No | None | P2, Hernandez et al., 2019 |
| 2 | Negative | AR IFNAR2 deficiency | Brazil | F | 35 | Sister died from YEL-AVD at 19 yr | YEL-AVD | 1999, 13 yr | Fever, hypotension, bleeding, hepatitis, thrombopenia | Not tested | No | None | P1, this report |
| 3 | Positive | Negative | Germany | M | 62 | — | YEL-AND/YEL-AVD | 2016, 57 yr | Fever, meningo-encephalitis, hepatitis | Urine | Influenza B pneumonia, 59 yr | None | P2, this report |
| 4 | Positive | Negative | Brazil | F | 50 | — | YEL-AVD | 2017, 47 yr | Fever, shock, renal insufficiency, hepatic insufficiency, thrombopenia | Blood | No | SLE (47 yr) | P3, this report |
| 5 | Positive | Negative | US | M | 80 | — | YEL-AVD | 2004, 64 yr | Fever, shock, renal insufficiency, thrombopenia, hepatitis | Blood | No | None | P4, this report |
| 6 | Negative | Negative | Brazil | M | 25 | 2 siblings (brother, aged 32 yr and sister, aged 32 yr) died from YEL-AVD | YEL-AVD | 2018, 28 yr | Fever, nausea, vomiting, headache, hepatitis | Blood | No | None | — |
| 7 | Negative | Negative | Brazil | M | 25 | Father: myasthenia gravis | YEL-AND | 2017, 22 yr | Fever, headache, vomiting, dizziness | CSF | No | None | — |
| 8 | Negative | Negative | Belgium | M | 56 | - | YEL-AND | 2020, 56 yr | Fever, headache, cognitive problems | CSF | No | None | — |
F, female; M, male.
Coding regions of IFNAR1, IFNAR2, TYK2, JAK1, STAT1, STAT2, and IRF9.