Table 1.

Activation properties of wild type and mutant Nav1.4 and Nav1.5 sodium channels

ActivationActivation V1/2 versus peak amplitude
V1/2 (mV)knY-intercept (mV)Slope (mV/nA)R coefficient
Splice variants       
mNav1.5 −25.9 ± 0.55 8.2 ± 0.16 36 −22.4 ± 0.13 0.44 ± 0.01 0.45 
mNav1.5e −16.8 ± 0.45 9.0 ± 0.13 51 −14.2 ± 0.08 0.48 ± 0.01 0.40 
mNav1.5 + β3 −23.9 ± 1.05 7.9 ± 0.26 11 −20.9 ± 0.79 0.25 ± 0.06 0.15 
mNav1.5e + β3 −13.8 ± 0.76 8.9 ± 0.17 18 −10.8 ± 0.21 0.49 ± 0.03 0.52 
Single swaps       
mNav1.5-T206V −25.9 ± 0.57 7.8 ± 0.18 25 −21.2 ± 0.13 0.42 ± 0.01 0.73 
mNav1.5e-V206T −13.0 ± 0.47 9.6 ± 0.10 24 −10.5 ± 0.18 0.55 ± 0.04 0.30 
mNav1.5-T207S −18.2 ± 0.64 9.3 ± 0.15 17 −15.2 ± 0.21 0.68 ± 0.04 0.52 
mNav1.5e-S207T −20.3 ± 0.53 9.6 ± 0.14 26 −17.7 ± 0.13 0.40 ± 0.02 0.51 
mNav1.5-T207A −22.1 ± 0.56 8.3 ± 0.13 26 −18.9 ± 0.16 0.42 ± 0.02 0.48 
mNav1.5e-S207A −16.8 ± 0.49 9.5 ± 0.11 20 −14.5 ± 0.14 0.37 ± 0.02 0.53 
mNav1.5-F209N −25.2 ± 0.57 8.8 ± 0.13 18 −23.0 ± 0.23 0.40 ± 0.04 0.30 
mNav1.5e-N209F −15.5 ± 0.68 8.6 ± 0.14 21 −10.7 ± 0.15 0.60 ± 0.02 0.76 
mNav1.5-V210I −25.2 ± 1.01 8.1 ± 0.27 12 −20.6 ± 0.44 0.46 ± 0.04 0.53 
mNav1.5e-I210V −17.5 ± 0.64 9.2 ± 0.16 24 −13.6 ± 0.14 0.62 ± 0.02 0.68 
mNav1.5-D211K −20.1 ± 0.58 8.6 ± 0.10 24 −17.0 ± 0.19 0.52 ± 0.03 0.40 
mNav1.5e-K211D −23.2 ± 0.50 8.5 ± 0.14 30 −18.5 ± 0.15 0.48 ± 0.01 0.58 
mNav1.5-D211A −21.4 ± 0.75 8.8 ± 0.19 14 −17.9 ± 0.07 0.46 ± 0.01 0.60 
mNav1.5e-K211A −19.8 ± 0.50 8.5 ± 0.18 42 −15.7 ± 0.07 0.47 ± 0.01 0.56 
mNav1.5-V215L −27.0 ± 0.52 8.4 ± 0.16 24 −24.2 ± 0.12 0.44 ± 0.02 0.61 
mNav1.5e-L215V −12.7 ± 0.51 10.1 ± 0.12 21 −10.1 ± 0.18 0.55 ± 0.03 0.41 
mNav1.5-S234P −24.2 ± 0.71 8.1 ± 0.23 20 −19.9 ± 0.16 0.56 ± 0.02 0.73 
mNav1.5e-P234S −14.7 ± 0.48 9.9 ± 0.13 18 −12.4 ± 0.19 0.61 ± 0.04 0.39 
Double swaps       
mNav1.5-T207S-D211K −16.2 ± 0.50 9.3 ± 0.10 25 −13.3 ± 0.16 0.50 ± 0.02 0.43 
mNav1.5e-S207T-K211D −27.6 ± 0.51 8.8 ± 0.16 24 −23.9 ± 0.17 0.46 ± 0.02 0.51 
SCN4A       
Mys-P2A-mNav1.4 + β3 −2.3 ± 0.65 8.8 ± 0.21 13 0.48 ± 0.31 1.4 ± 0.14 0.43 
Mys-P2A-mNav1.4-T207S-D211K + β3 5.7 ± 0.50 9.0 ± 0.24 25 5.9 ± 0.18 0.12 ± 0.02 0.0032 
ActivationActivation V1/2 versus peak amplitude
V1/2 (mV)knY-intercept (mV)Slope (mV/nA)R coefficient
Splice variants       
mNav1.5 −25.9 ± 0.55 8.2 ± 0.16 36 −22.4 ± 0.13 0.44 ± 0.01 0.45 
mNav1.5e −16.8 ± 0.45 9.0 ± 0.13 51 −14.2 ± 0.08 0.48 ± 0.01 0.40 
mNav1.5 + β3 −23.9 ± 1.05 7.9 ± 0.26 11 −20.9 ± 0.79 0.25 ± 0.06 0.15 
mNav1.5e + β3 −13.8 ± 0.76 8.9 ± 0.17 18 −10.8 ± 0.21 0.49 ± 0.03 0.52 
Single swaps       
mNav1.5-T206V −25.9 ± 0.57 7.8 ± 0.18 25 −21.2 ± 0.13 0.42 ± 0.01 0.73 
mNav1.5e-V206T −13.0 ± 0.47 9.6 ± 0.10 24 −10.5 ± 0.18 0.55 ± 0.04 0.30 
mNav1.5-T207S −18.2 ± 0.64 9.3 ± 0.15 17 −15.2 ± 0.21 0.68 ± 0.04 0.52 
mNav1.5e-S207T −20.3 ± 0.53 9.6 ± 0.14 26 −17.7 ± 0.13 0.40 ± 0.02 0.51 
mNav1.5-T207A −22.1 ± 0.56 8.3 ± 0.13 26 −18.9 ± 0.16 0.42 ± 0.02 0.48 
mNav1.5e-S207A −16.8 ± 0.49 9.5 ± 0.11 20 −14.5 ± 0.14 0.37 ± 0.02 0.53 
mNav1.5-F209N −25.2 ± 0.57 8.8 ± 0.13 18 −23.0 ± 0.23 0.40 ± 0.04 0.30 
mNav1.5e-N209F −15.5 ± 0.68 8.6 ± 0.14 21 −10.7 ± 0.15 0.60 ± 0.02 0.76 
mNav1.5-V210I −25.2 ± 1.01 8.1 ± 0.27 12 −20.6 ± 0.44 0.46 ± 0.04 0.53 
mNav1.5e-I210V −17.5 ± 0.64 9.2 ± 0.16 24 −13.6 ± 0.14 0.62 ± 0.02 0.68 
mNav1.5-D211K −20.1 ± 0.58 8.6 ± 0.10 24 −17.0 ± 0.19 0.52 ± 0.03 0.40 
mNav1.5e-K211D −23.2 ± 0.50 8.5 ± 0.14 30 −18.5 ± 0.15 0.48 ± 0.01 0.58 
mNav1.5-D211A −21.4 ± 0.75 8.8 ± 0.19 14 −17.9 ± 0.07 0.46 ± 0.01 0.60 
mNav1.5e-K211A −19.8 ± 0.50 8.5 ± 0.18 42 −15.7 ± 0.07 0.47 ± 0.01 0.56 
mNav1.5-V215L −27.0 ± 0.52 8.4 ± 0.16 24 −24.2 ± 0.12 0.44 ± 0.02 0.61 
mNav1.5e-L215V −12.7 ± 0.51 10.1 ± 0.12 21 −10.1 ± 0.18 0.55 ± 0.03 0.41 
mNav1.5-S234P −24.2 ± 0.71 8.1 ± 0.23 20 −19.9 ± 0.16 0.56 ± 0.02 0.73 
mNav1.5e-P234S −14.7 ± 0.48 9.9 ± 0.13 18 −12.4 ± 0.19 0.61 ± 0.04 0.39 
Double swaps       
mNav1.5-T207S-D211K −16.2 ± 0.50 9.3 ± 0.10 25 −13.3 ± 0.16 0.50 ± 0.02 0.43 
mNav1.5e-S207T-K211D −27.6 ± 0.51 8.8 ± 0.16 24 −23.9 ± 0.17 0.46 ± 0.02 0.51 
SCN4A       
Mys-P2A-mNav1.4 + β3 −2.3 ± 0.65 8.8 ± 0.21 13 0.48 ± 0.31 1.4 ± 0.14 0.43 
Mys-P2A-mNav1.4-T207S-D211K + β3 5.7 ± 0.50 9.0 ± 0.24 25 5.9 ± 0.18 0.12 ± 0.02 0.0032 
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