| Variable . | E13.5 . | E14.5 . | E15.5 . | E16.5 . | E17.5 . | E18.5 . | E19.5 . |
|---|---|---|---|---|---|---|---|
| Litters | |||||||
| Animals per litter | 8 ± 2 | 9 ± 2 | 10 ± 2 | 9 ± 1 | 8 ± 1 | 8 ± 2 | 6 ± 2 |
| Number of litters | 7 | 5 | 4 | 8 | 10 | 48 | 12 |
| Mendelian distribution | |||||||
| WT/KO/HET | 15/11/26 | 11/13/24 | 11/11/14 | 14/15/40 | 26/11/43 | 95/94/205 | 15/10/40 |
| Total number of fetuses | 57 | 44 | 39a | 69 | 81b | 401c | 68 |
| Sex distribution (M/F)d | |||||||
| WT | 21/9 | 16/9 | 12/18 | 17/11 | 13/16 | 17/9 | 5/18 |
| KO | 10/10 | 11/18 | 14/14 | 10/10 | 12/0 | 12/8 | 0/14 |
| HE | 37/12 | 34/12 | 15/25 | 31/20 | 26/31 | 17/20 | 37/18 |
| Omphalocelee | |||||||
| WT | 2/26 (8%) | 0/95 (0%) | 0/15 (0%) | ||||
| KO | 11/11 (100%) | 86/94 (92%) | 10/10 (100%) | ||||
| HET | 3/45 (7%) | 15/205 (7%) | 6/40 (15%) |
| Variable . | E13.5 . | E14.5 . | E15.5 . | E16.5 . | E17.5 . | E18.5 . | E19.5 . |
|---|---|---|---|---|---|---|---|
| Litters | |||||||
| Animals per litter | 8 ± 2 | 9 ± 2 | 10 ± 2 | 9 ± 1 | 8 ± 1 | 8 ± 2 | 6 ± 2 |
| Number of litters | 7 | 5 | 4 | 8 | 10 | 48 | 12 |
| Mendelian distribution | |||||||
| WT/KO/HET | 15/11/26 | 11/13/24 | 11/11/14 | 14/15/40 | 26/11/43 | 95/94/205 | 15/10/40 |
| Total number of fetuses | 57 | 44 | 39a | 69 | 81b | 401c | 68 |
| Sex distribution (M/F)d | |||||||
| WT | 21/9 | 16/9 | 12/18 | 17/11 | 13/16 | 17/9 | 5/18 |
| KO | 10/10 | 11/18 | 14/14 | 10/10 | 12/0 | 12/8 | 0/14 |
| HE | 37/12 | 34/12 | 15/25 | 31/20 | 26/31 | 17/20 | 37/18 |
| Omphalocelee | |||||||
| WT | 2/26 (8%) | 0/95 (0%) | 0/15 (0%) | ||||
| KO | 11/11 (100%) | 86/94 (92%) | 10/10 (100%) | ||||
| HET | 3/45 (7%) | 15/205 (7%) | 6/40 (15%) |
Data are mean ± SD, n, or n/total n in group (%). At E18.5, total number of animals is higher than for litter size, as it combines numbers from two cohorts.
Genotype could not be determined in three animals.
Genotype could not be determined in one animal.
Genotype could not be determined in seven animals.
Sex was genotyped in a subpopulation.
No numbers are given for E13.5–E16.5, as an omphalocele is physiological until E16.5 and is present in all fetuses.