Table 2.
Litter size, Mendelian and sex distribution, and prevalence of omphalocele
VariableE13.5E14.5E15.5E16.5E17.5E18.5E19.5
Litters        
Animals per litter 8 ± 2 9 ± 2 10 ± 2 9 ± 1 8 ± 1 8 ± 2 6 ± 2 
Number of litters 7 5 4 8 10 48 12 
Mendelian distribution        
WT/KO/HET 15/11/26 11/13/24 11/11/14 14/15/40 26/11/43 95/94/205 15/10/40 
Total number of fetuses 57 44 39a 69 81b 401c 68 
Sex distribution (M/F)d        
WT 21/9 16/9 12/18 17/11 13/16 17/9 5/18 
KO 10/10 11/18 14/14 10/10 12/0 12/8 0/14 
HE 37/12 34/12 15/25 31/20 26/31 17/20 37/18 
Omphalocelee        
WT     2/26 (8%) 0/95 (0%) 0/15 (0%) 
KO     11/11 (100%) 86/94 (92%) 10/10 (100%) 
HET     3/45 (7%) 15/205 (7%) 6/40 (15%) 

Data are mean ± SD, n, or n/total n in group (%). At E18.5, total number of animals is higher than for litter size, as it combines numbers from two cohorts.

a

Genotype could not be determined in three animals.

b

Genotype could not be determined in one animal.

c

Genotype could not be determined in seven animals.

d

Sex was genotyped in a subpopulation.

e

No numbers are given for E13.5–E16.5, as an omphalocele is physiological until E16.5 and is present in all fetuses.

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