Table 2. Permeabilized cardiac myocyte... | Rockefeller University Press

Table 2.

Permeabilized cardiac myocyte preparation force-velocity and power-load characteristics at long and short SL during submaximal Ca²⁺ activation

	SL (µm)	a/P_o	F_opt (P/P_o)	V_opt(ML·s⁻¹)	V_max(ML·s⁻¹)	Peak absolute power output (µW mg⁻¹)	PNPO (P/P_o ML·s⁻¹)
Control
Long SL	2.22 ± 0.02	0.16 ± 0.04	0.26 ± 0.03	0.44 ± 0.04	1.84 ± 0.16	3.52 ± 0.98	0.118 ± 0.017
Short SL	1.93 ± 0.01	0.23 ± 0.05	0.29 ± 0.02	0.35 ± 0.05	1.23 ± 0.18	1.36 ± 0.35	0.100 ± 0.017
cMyBP-C 3tSD
Long SL	2.27 ± 0.02	0.21 ± 0.04	0.28 ± 0.02	0.48 ± 0.04	1.71 ± 0.14	3.61 ± 0.58	0.135 ± 0.018
Short SL	1.94 ± 0.01	0.23 ± 0.04	0.29 ± 0.02	0.33 ± 0.04	1.14 ± 0.10	1.27 ± 0.27	0.099 ± 0.015
cMyBP-C 3tSA
Long SL	2.24 ± 0.02	0.27 ± 0.05	0.31 ± 0.02	0.38 ± 0.06	1.30 ± 0.19	2.94 ± 0.73	0.118 ± 0.019
Short SL	1.94 ± 0.01	0.28 ± 0.05	0.31 ± 0.02	0.37 ± 0.05	1.23 ± 0.14	1.48 ± 0.31	0.116 ± 0.020
cMyBP-C KO
Long SL	2.22 ± 0.02	0.66 ± 0.21^a	0.36 ± 0.03	0.43 ± 0.04	1.28 ± 0.17	3.10 ± 0.39	0.154 ± 0.021
Short SL	1.92 ± 0.01	0.96 ± 0.35^a	0.37 ± 0.03	0.41 ± 0.05	1.16 ± 0.10	1.56 ± 0.29	0.157 ± 0.026

	SL (µm)	a/P_o	F_opt (P/P_o)	V_opt(ML·s⁻¹)	V_max(ML·s⁻¹)	Peak absolute power output (µW mg⁻¹)	PNPO (P/P_o ML·s⁻¹)
Control
Long SL	2.22 ± 0.02	0.16 ± 0.04	0.26 ± 0.03	0.44 ± 0.04	1.84 ± 0.16	3.52 ± 0.98	0.118 ± 0.017
Short SL	1.93 ± 0.01	0.23 ± 0.05	0.29 ± 0.02	0.35 ± 0.05	1.23 ± 0.18	1.36 ± 0.35	0.100 ± 0.017
cMyBP-C 3tSD
Long SL	2.27 ± 0.02	0.21 ± 0.04	0.28 ± 0.02	0.48 ± 0.04	1.71 ± 0.14	3.61 ± 0.58	0.135 ± 0.018
Short SL	1.94 ± 0.01	0.23 ± 0.04	0.29 ± 0.02	0.33 ± 0.04	1.14 ± 0.10	1.27 ± 0.27	0.099 ± 0.015
cMyBP-C 3tSA
Long SL	2.24 ± 0.02	0.27 ± 0.05	0.31 ± 0.02	0.38 ± 0.06	1.30 ± 0.19	2.94 ± 0.73	0.118 ± 0.019
Short SL	1.94 ± 0.01	0.28 ± 0.05	0.31 ± 0.02	0.37 ± 0.05	1.23 ± 0.14	1.48 ± 0.31	0.116 ± 0.020
cMyBP-C KO
Long SL	2.22 ± 0.02	0.66 ± 0.21^a	0.36 ± 0.03	0.43 ± 0.04	1.28 ± 0.17	3.10 ± 0.39	0.154 ± 0.021
Short SL	1.92 ± 0.01	0.96 ± 0.35^a	0.37 ± 0.03	0.41 ± 0.05	1.16 ± 0.10	1.56 ± 0.29	0.157 ± 0.026

Values are mean ± SEM. a, constant with dimension of force from the second equation relative to isometric force (P_o); F_opt, relative force at peak power; ML, muscle length; P/P_o, force relative to isometric force; V_opt, velocity at F_opt.

P < 0.05 versus Control, cMyBP-C 3tSD, and cMyBP-C 3tSA.

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