Table 2. Myofilament model parameters... | Rockefeller University Press

Table 2.

Myofilament model parameters

Parameter	Description	IVM WT fit	IVM E192K fit	WT twitch fit	E192K twitch
$γ (m o l^{- 1} k J)$	Tropomyosin chain stiffness	33.15	23.3	42	29.4
$λ$	Probability of calcium-independent state transitions	0.03	0.03	0.06	0.06
$k_{C a}_{+} (u M^{- 1} m s^{- 1})$	Forward rate for calcium binding to troponin	1	1	0.5	0.5
$K_{C a}$	Calcium-binding equilibrium constant	1.4	1.4	1	1
$k_{B C}^{r e f} (m s^{- 1})$	Forward rate for blocked-to-closed transition	2.39	2.39	1	1
$K_{B C}$	Blocked-to-closed state transition equilibrium constant	7	4.2	0.9	0.54
$f^{r e f} (m s^{- 1})$	Forward rate for closed-to-open transition	0.0999	0.0999	0.2	0.2
$δ$	Myosin duty cycle	0.17	0.17	0.60	0.60

Parameter	Description	IVM WT fit	IVM E192K fit	WT twitch fit	E192K twitch
$γ (m o l^{- 1} k J)$	Tropomyosin chain stiffness	33.15	23.3	42	29.4
$λ$	Probability of calcium-independent state transitions	0.03	0.03	0.06	0.06
$k_{C a}_{+} (u M^{- 1} m s^{- 1})$	Forward rate for calcium binding to troponin	1	1	0.5	0.5
$K_{C a}$	Calcium-binding equilibrium constant	1.4	1.4	1	1
$k_{B C}^{r e f} (m s^{- 1})$	Forward rate for blocked-to-closed transition	2.39	2.39	1	1
$K_{B C}$	Blocked-to-closed state transition equilibrium constant	7	4.2	0.9	0.54
$f^{r e f} (m s^{- 1})$	Forward rate for closed-to-open transition	0.0999	0.0999	0.2	0.2
$δ$	Myosin duty cycle	0.17	0.17	0.60	0.60

Bold values are parameters that were altered in the model. IVM, in vitro motility.