Table 2. Parameter values for CN-CD and... | Rockefeller University Press

Table 2.

Parameter values for CN-CD and SM-CD models and variants

		Excitable P-L/D charge difference (CD) model
	Notes	CN-CD	MN-CD	SM-CD	WD-CD	LA-CD
Parameter	Nature of model’s steady state →→	P-L domin’d st-st nonminimal (neuron)	P-L domin’d st-st / minimal (no co-transporter)	Donnan domin’d st-st / minimal (healthy SMF)	P-L domin’d st-st / minimal (counterfactual)	Donnan domin’d st-st / minimal (DMD-like)
C_m		20 pF	20 pF	20 pF	20 pF	20 pF
SA (from C_m)	(0.01 pF/µm²)	2,000 µm²	2,000 µm²	2,000 µm²	2,000 µm²	2,000 µm²
P_Na		2 µm³/s	2 µm³/s	0.3 µm³/s	1.06 µm³/s	0.3 µm³/s
P_K		20 µm³/s	20 µm³/s	10 µm³/s	36.7 µm³/s	10 µm³/s
P_Cl		2.5 µm³/s	2.5 µm³/s	30 µm³/s	2.5 µm³/s	30 µm³/s
P_Na:P_K:P_Cl	P_ionX ratios	0.1:1:0.125	0.1:1:0.125	0.03:1:3	0.03:1:0.07	0.03:1:3
Impedance⁻¹	(Summed P_ionX)	24.5 µm³/s	22.5 µm³/s	40.3 µm³/s	40.3 µm³/s	40.3 µm³/s
P_H2O		2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)
N_Ai		296 fmol	296 fmol	299.2 fmol	299.2 fmol	298.4 fmol
Pump as ATPase	Max ATP/s or 100%	566 amol/s	566 amol/s	566 amol/s	566 amol/s	170 amol/s
I_maxNaKpump	Max I_NaKpump	54.5 pA	54.5 pA	54.5 pA	54.5 pA	16.35 pA
Max P_Nav	Like H-H g_max	800 µm³/s	800 µm³/s	2,400 µm³/s	2,400 m³/s	2,400 µm³/s
Max P_Kv	Like H-H g_max	400 µm³/s	400 µm³/s	1,200 µm³/s	1,200 m³/s	1,200 µm³/s
U_KCl	(Strength)	1.3 (fmol/s)/(J/Coul)	0	0	0	0
Max P_Clv	(Pathological)	19.5 µm³/s	19.5 µm³/s	0	0	0
Electrolytes (mM): extracellular [fixed] and intracellular (calculated at steady state)
[Sol]_{e, i}	Total solutes	[310] & (310)	[310] & (310)	[310] & (310)	[310] & (310)	[310] & (310)
[Na⁺]_{e, i}	Sodium	[152] & (10)	[152] & (9.8)	[152] & (3.7)	[152] & (6.8)	[152] & (6.5)
[K⁺]_{e, i}	Potassium	[3] & (145)	[3] & (145.2)	[3] & (151.3)	[3] & (148.2)	[3] & (148.5)
[Cl⁻]_{e, i}	Chloride	[135] & (7)	[135] & (12.2)	[135] & (5.4)	[135] & (5.4)	[135] & (5.5)
[A⁻]_{e, i}	Impermeant	[20] & (148)	[20] & (142.8)	[20] & (149.6)	[20] & (149.6)	[20] & (149.5)
Calculated steady-state (resting-state) values of P-L/D systems with above values
Vol_cell	(Volume)	2,000 µm³	2,072 µm³	2,000 µm³	2,000 µm³	2,000 µm³
V_m	(V_rest)	−65.5 mV	−64.3 mV	−86.0 mV	−86.0 mV	−85.6 mV
[Sol]_i	[Solutes]_cytoplasm	310 mM	310 mM	310 mM	310 mM	310 mM
E_Na	(Nernst pot’l)	72.6 mV	73.1 mV	99.2 mV	82.9 mV	84.0 mV
E_K	(Nernst pot’l)	−103.6 mV	−103.6 mV	−104.7 mV	−104.2 mV	−104.2 mV
E_Cl	(Nernst pot’l)	−79.0 mV	−64.3 mV	−86.0 mV	−86.0 mV	−85.6 mV
I_Naleak (st-st)	(Through P_Na)	−78.2 pA	−77.1 pA	−14.75 pA	−52.1 pA	−14.66 pA
I_Nav (st-st)	(Through P_Nav)	−0.07 pA	−0.14 pA	−2.3 × 10⁻⁷ pA	−2.4 × 10⁻⁷ pA	−3.3 × 10⁻⁷ pA
m	(H-H)	0.013	0.013	0.000	0.000	0.000
h	(H-H)	0.987	0.987	1.000	1.000	1.0000
m³h	(H-H)	2.2 × 10⁻⁶	2.2 × 10⁻⁶	1.75 × 10⁻¹²	2.0 × 10⁻¹²	2.8 × 10⁻¹²
n	(H-H)	0.003	0.003	0.000	4.8 × 10⁻⁵	5.3 × 10⁻⁵
ATP/s (st-st)	Consumption	270.9 amol/s	267.3 amol/s	51.0 amol/s	180.4 amol/s	50.7 amol/s
Pump reserve	Max ATP/s /consumption	2.1-fold	2.12-fold	11.1-fold	3.1-fold	3.4-fold
Miscellaneous
Vol_cellDonnanEq	(Notional)	14,000 µm³	14,000 µm³	14,960 µm³	14,961 µm³	14, 952 µm³
Vol_cellrupture	(Bilayer limit)	8,920 µm³	8,920 µm³	8,920 µm³	8,920 µm³	8,920 µm³

		Excitable P-L/D charge difference (CD) model
	Notes	CN-CD	MN-CD	SM-CD	WD-CD	LA-CD
Parameter	Nature of model’s steady state →→	P-L domin’d st-st nonminimal (neuron)	P-L domin’d st-st / minimal (no co-transporter)	Donnan domin’d st-st / minimal (healthy SMF)	P-L domin’d st-st / minimal (counterfactual)	Donnan domin’d st-st / minimal (DMD-like)
C_m		20 pF	20 pF	20 pF	20 pF	20 pF
SA (from C_m)	(0.01 pF/µm²)	2,000 µm²	2,000 µm²	2,000 µm²	2,000 µm²	2,000 µm²
P_Na		2 µm³/s	2 µm³/s	0.3 µm³/s	1.06 µm³/s	0.3 µm³/s
P_K		20 µm³/s	20 µm³/s	10 µm³/s	36.7 µm³/s	10 µm³/s
P_Cl		2.5 µm³/s	2.5 µm³/s	30 µm³/s	2.5 µm³/s	30 µm³/s
P_Na:P_K:P_Cl	P_ionX ratios	0.1:1:0.125	0.1:1:0.125	0.03:1:3	0.03:1:0.07	0.03:1:3
Impedance⁻¹	(Summed P_ionX)	24.5 µm³/s	22.5 µm³/s	40.3 µm³/s	40.3 µm³/s	40.3 µm³/s
P_H2O		2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)	2 µm³/(s Pa)
N_Ai		296 fmol	296 fmol	299.2 fmol	299.2 fmol	298.4 fmol
Pump as ATPase	Max ATP/s or 100%	566 amol/s	566 amol/s	566 amol/s	566 amol/s	170 amol/s
I_maxNaKpump	Max I_NaKpump	54.5 pA	54.5 pA	54.5 pA	54.5 pA	16.35 pA
Max P_Nav	Like H-H g_max	800 µm³/s	800 µm³/s	2,400 µm³/s	2,400 m³/s	2,400 µm³/s
Max P_Kv	Like H-H g_max	400 µm³/s	400 µm³/s	1,200 µm³/s	1,200 m³/s	1,200 µm³/s
U_KCl	(Strength)	1.3 (fmol/s)/(J/Coul)	0	0	0	0
Max P_Clv	(Pathological)	19.5 µm³/s	19.5 µm³/s	0	0	0
Electrolytes (mM): extracellular [fixed] and intracellular (calculated at steady state)
[Sol]_{e, i}	Total solutes	[310] & (310)	[310] & (310)	[310] & (310)	[310] & (310)	[310] & (310)
[Na⁺]_{e, i}	Sodium	[152] & (10)	[152] & (9.8)	[152] & (3.7)	[152] & (6.8)	[152] & (6.5)
[K⁺]_{e, i}	Potassium	[3] & (145)	[3] & (145.2)	[3] & (151.3)	[3] & (148.2)	[3] & (148.5)
[Cl⁻]_{e, i}	Chloride	[135] & (7)	[135] & (12.2)	[135] & (5.4)	[135] & (5.4)	[135] & (5.5)
[A⁻]_{e, i}	Impermeant	[20] & (148)	[20] & (142.8)	[20] & (149.6)	[20] & (149.6)	[20] & (149.5)
Calculated steady-state (resting-state) values of P-L/D systems with above values
Vol_cell	(Volume)	2,000 µm³	2,072 µm³	2,000 µm³	2,000 µm³	2,000 µm³
V_m	(V_rest)	−65.5 mV	−64.3 mV	−86.0 mV	−86.0 mV	−85.6 mV
[Sol]_i	[Solutes]_cytoplasm	310 mM	310 mM	310 mM	310 mM	310 mM
E_Na	(Nernst pot’l)	72.6 mV	73.1 mV	99.2 mV	82.9 mV	84.0 mV
E_K	(Nernst pot’l)	−103.6 mV	−103.6 mV	−104.7 mV	−104.2 mV	−104.2 mV
E_Cl	(Nernst pot’l)	−79.0 mV	−64.3 mV	−86.0 mV	−86.0 mV	−85.6 mV
I_Naleak (st-st)	(Through P_Na)	−78.2 pA	−77.1 pA	−14.75 pA	−52.1 pA	−14.66 pA
I_Nav (st-st)	(Through P_Nav)	−0.07 pA	−0.14 pA	−2.3 × 10⁻⁷ pA	−2.4 × 10⁻⁷ pA	−3.3 × 10⁻⁷ pA
m	(H-H)	0.013	0.013	0.000	0.000	0.000
h	(H-H)	0.987	0.987	1.000	1.000	1.0000
m³h	(H-H)	2.2 × 10⁻⁶	2.2 × 10⁻⁶	1.75 × 10⁻¹²	2.0 × 10⁻¹²	2.8 × 10⁻¹²
n	(H-H)	0.003	0.003	0.000	4.8 × 10⁻⁵	5.3 × 10⁻⁵
ATP/s (st-st)	Consumption	270.9 amol/s	267.3 amol/s	51.0 amol/s	180.4 amol/s	50.7 amol/s
Pump reserve	Max ATP/s /consumption	2.1-fold	2.12-fold	11.1-fold	3.1-fold	3.4-fold
Miscellaneous
Vol_cellDonnanEq	(Notional)	14,000 µm³	14,000 µm³	14,960 µm³	14,961 µm³	14, 952 µm³
Vol_cellrupture	(Bilayer limit)	8,920 µm³	8,920 µm³	8,920 µm³	8,920 µm³	8,920 µm³

CN-CD entries are from Table 1 of Dijkstra et al. (2016). Parameter terms: see List of abbreviations. As per Dijkstra et al. (2016), permeabilities (in µm³/s) are particular to the invariant membrane area here (2,000 µm²). Constants: F, Faraday constant, 96,485.333 coulombs/mol; R universal gas constant, 8.31446 J mol⁻¹°K⁻¹; absolute temperature, 310°K; specific membrane capacitance, 0.01 pF/µm².

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