Table 1.
X-ray diffraction data processing statistics and model refinement parameters
PDB accession no.7AHS
Space group P212121 
Cell dimensions 
a, b, c, Å 85.20, 87.34, 161.58 
 α, β, γ, ° 90, 90, 90 
Molecules in asymmetric unit 
X-ray data  
X-ray source SLS PX III 
Detector PILATUS 2MF 
Wavelength, Å 1.00003 
Resolution, Å 43.67-2.05 (2.1-2.05) 
Unique reflections 76,413 (5,256) 
Multiplicity 13.4 (12.8) 
Completeness (%) 100 (100) 
<I/σ (I)> 13.45 (1.18) 
Rmeas (%) 19 (236) 
CC1/2 (%) 99.9 (37.6) 
Refinement  
Reflections work/R-free sets 74,495/1,841 
Protein atoms/waters 8,884/1,004 
Ligands EDO × 11, GOL × 1, SO4 × 6 
Rfactor/Rfree,18.3/23.5 
RMSD bond length, Å/angle, ° 0.009/1.215 
Ramachandranfavored/outliers, % 97.50/0.19 
PDB accession no.7AHS
Space group P212121 
Cell dimensions 
a, b, c, Å 85.20, 87.34, 161.58 
 α, β, γ, ° 90, 90, 90 
Molecules in asymmetric unit 
X-ray data  
X-ray source SLS PX III 
Detector PILATUS 2MF 
Wavelength, Å 1.00003 
Resolution, Å 43.67-2.05 (2.1-2.05) 
Unique reflections 76,413 (5,256) 
Multiplicity 13.4 (12.8) 
Completeness (%) 100 (100) 
<I/σ (I)> 13.45 (1.18) 
Rmeas (%) 19 (236) 
CC1/2 (%) 99.9 (37.6) 
Refinement  
Reflections work/R-free sets 74,495/1,841 
Protein atoms/waters 8,884/1,004 
Ligands EDO × 11, GOL × 1, SO4 × 6 
Rfactor/Rfree,18.3/23.5 
RMSD bond length, Å/angle, ° 0.009/1.215 
Ramachandranfavored/outliers, % 97.50/0.19 

Values in parentheses are for the highest resolution shell.

EDO, ethylene glycol; GOL, glycerol; SO4, sulfate. (h,i). Rwork = ∑hkl||Fo|–|Fc||/∑|Fo|, where Fo is the observed structure factor amplitude and Fc is the structure‐factor amplitude calculated from the model. Rfree is the same as Rwork except that it was only calculated using a subset, 5%, of the data that are not included in any refinement calculations. Rmeas, defined as Rmeas = Σh (nh/nh − 1)1/2 Σi|<Ih> − Ih,i|/ΣhΣi Ih,I, where nh denotes multiplicity. CC1/2=στ2στ2+σε2=σγ2-12σε2σγ2+12σε2. This requires calculation of σγ2, the variance of the average intensities, and σε2, the average of the variances of the averaged (merged) intensities.

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