Table 2. Comparison of parameters for... | Rockefeller University Press

Table 2.

Comparison of parameters for the twitch contraction simulations with the six-state model (including PS) of isometric half-sarcomere (Figs. 3, S2, and S4) and trabeculae at fixed length Fig. 5, A and B, and Fig. 6 A

		Isometric HS		Fixed-length trabeculae
XB cycle	Parameter	22°C^a	27.2°C^b	22°C^a^,^c	27.2°C^b^,^c	30°C^c
Myosin–actin binding rate	${k_{+}^{o}}_{A}$	72	125	140	226	256
Myosin–actin detachment rate	$k_{- A}^{o}$	10	21	22	46	66
Power stroke Gibbs energy change	$Δ G_{s t r o k e}$	−15.3	−15.3	−13	−13	−13
ADP release rate	$k_{+ D}^{o}$	40	60	40	60	92

		Isometric HS		Fixed-length trabeculae
XB cycle	Parameter	22°Ca	27.2°Cb	22°Ca^,c	27.2°Cb^,c	30°Cc
Myosin–actin binding rate	${k_{+}^{o}}_{A}$	72	125	140	226	256
Myosin–actin detachment rate	$k_{- A}^{o}$	10	21	22	46	66
Power stroke Gibbs energy change	$Δ G_{s t r o k e}$	−15.3	−15.3	−13	−13	−13
ADP release rate	$k_{+ D}^{o}$	40	60	40	60	92

Displayed are only parameters that are different from those shown in Table 1. Rates ${k_{+}^{o}}_{A},$ $k_{- A}^{o},$ and $k_{+ D}^{o}$ are per second; $Δ G_{s t r o k e}$ is in units of k_BT. HS, half-sarcomere; XB, cross-bridge.

Janssen and de Tombe (1997).

Caremani et al. (2016).

Janssen et al. (2002) at slightly different temperatures of 22.5°C and 27.5°C; the rate $k_{+A}^{o}$ is slightly higher, 149 s⁻¹ at 22.5°C.

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