Table 2. Ang 1–7 does not reverse the... | Rockefeller University Press

Table 2.

Ang 1–7 does not reverse the prolongation of the tetanic time to peak in EDL and half-relaxation time of EDL and soleus associated with 4-wk denervation in both wild-type and MasR^−/− mice

Muscle	Condition	Wild type		MasR^−/−
Muscle	Condition	Time to peak (ms)	Half-relaxation time (ms)	Time to peak (ms)	Half-relaxation time (ms)
EDL	Innervated	118.8 ± 11.0	19.0 ± 2.9	118.5 ± 22.2	27.8 ± 1.4
EDL	Denervated	196.9 ± 3.8^a	44.8 ± 2.7^a	178.4 ± 18.7^a	53.4 ± 3.0^a
EDL	Denervated Ang 1–7	197.4 ± 2.7^a	45.2 ± 2.5^a	191.7 ± 8.4^a	63.8 ± 13.1^a,^b
Soleus	Innervated	204.6 ± 0.7	43.3 ± 1.7	211.8 ± 1.2	52.3 ± 3.6
Soleus	Denervated	208.0 ± 6.0	95.3 ± 5.9^a	213.4 ± 1.4	103.8 ± 10.2^a
Soleus	Denervated Ang 1–7	210.0 ± 5.3	97.6 ± 11.7^a	212.0 ± 5.0	85.2 ± 11.3^a

Muscle	Condition	Wild type		MasR^−/−
Muscle	Condition	Time to peak (ms)	Half-relaxation time (ms)	Time to peak (ms)	Half-relaxation time (ms)
EDL	Innervated	118.8 ± 11.0	19.0 ± 2.9	118.5 ± 22.2	27.8 ± 1.4
EDL	Denervated	196.9 ± 3.8^a	44.8 ± 2.7^a	178.4 ± 18.7^a	53.4 ± 3.0^a
EDL	Denervated Ang 1–7	197.4 ± 2.7^a	45.2 ± 2.5^a	191.7 ± 8.4^a	63.8 ± 13.1^a,^b
Soleus	Innervated	204.6 ± 0.7	43.3 ± 1.7	211.8 ± 1.2	52.3 ± 3.6
Soleus	Denervated	208.0 ± 6.0	95.3 ± 5.9^a	213.4 ± 1.4	103.8 ± 10.2^a
Soleus	Denervated Ang 1–7	210.0 ± 5.3	97.6 ± 11.7^a	212.0 ± 5.0	85.2 ± 11.3^a

Ang 1–7 was delivered using an osmotic pump at a rate of 15 mg/kg/d. Tetanic contractions for EDL and soleus were respectively elicited at 200 and 140 Hz. Data are presented as mean ± SE of five or six muscles.

Mean value is significantly different from that of innervated muscles (ANOVA and LSD, P < 0.05).

Mean value is significantly different from CD-1 muscles (ANOVA and LSD, P < 0.05).

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