Table 1. Ang 1–7 does not reverse the... | Rockefeller University Press

Table 1.

Ang 1–7 does not reverse the significant prolongation of twitch contraction associated with 4-wk denervation for both wild-type and MasR^−/− EDL and soleus

Muscle	Condition	Wild type		MasR^−/−
Muscle	Condition	Time to peak (ms)	Half-relaxation time (ms)	Time to peak (ms)	Half-relaxation time (ms)
EDL	Innervated	7.2 ± 1.1	5.8 ± 0.3	8.2 ± 0.8	10.2 ± 1.2
EDL	Denervated	14.8 ± 1.4^a	9.4 ± 1.1	13.4 ± 0.8^a	17.0 ± 1.5^a,^b
EDL	Denervated Ang 1–7	13.0 ± 1.1^a	11.9 ± 0.7^a	17.3 ± 4.2^a,^b	20.5 ± 5.3^a,^b
Soleus	Innervated	15.7 ± 0. 6	10.3 ± 1.1	13.3 ± 0.7	16.6 ± 2.24
Soleus	Denervated	33.7 ± 1.0^a	38.5 ± 4.9^a	28.9 ± 1.7^a	43.9 ± 4.5^a
Soleus	Denervated Ang 1–7	34.7 ± 1.1^a	37.2 ± 2.7^a	25.3 ± 3.5^a,^b	35.6 ± 9.1^a

Muscle	Condition	Wild type		MasR^−/−
Muscle	Condition	Time to peak (ms)	Half-relaxation time (ms)	Time to peak (ms)	Half-relaxation time (ms)
EDL	Innervated	7.2 ± 1.1	5.8 ± 0.3	8.2 ± 0.8	10.2 ± 1.2
EDL	Denervated	14.8 ± 1.4a	9.4 ± 1.1	13.4 ± 0.8a	17.0 ± 1.5a,b
EDL	Denervated Ang 1–7	13.0 ± 1.1a	11.9 ± 0.7a	17.3 ± 4.2a,b	20.5 ± 5.3a,b
Soleus	Innervated	15.7 ± 0. 6	10.3 ± 1.1	13.3 ± 0.7	16.6 ± 2.24
Soleus	Denervated	33.7 ± 1.0a	38.5 ± 4.9a	28.9 ± 1.7a	43.9 ± 4.5a
Soleus	Denervated Ang 1–7	34.7 ± 1.1a	37.2 ± 2.7a	25.3 ± 3.5a,b	35.6 ± 9.1a

Ang 1–7 was delivered using an osmotic pump at a rate of 15 mg/kg/d. Data are presented as mean ± SE of five or six muscles.

Mean value is significantly different from that of innervated muscles (ANOVA and LSD, P < 0.05).

Mean value is significantly different from CD-1 muscles (ANOVA and LSD, P < 0.05).

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