| FXYD protein . | Other name . | Expression pattern . | Effects on NKA . | Posttranslational modifications and effects on NKA . | Physiological/pathological role . |
|---|---|---|---|---|---|
| FXYD1 | PLM | Expresses in multiple tissue types | ↓Sodium affinity (Crambert et al., 2002; Despa et al., 2005; Bossuyt et al., 2009; Meyer et al., 2020) | Phosphorylation at Ser63, Ser68, and Ser69 | PLM is required for the sympathetic simulation of the NKA in cardiomyocytes (Despa et al., 2005) |
| ↑NKA activity (Fuller et al., 2009; Despa et al., 2005), glutathionylation at Cys42 ↑NKA activity (Bibert et al., 2011), palmitoylation at Cys40 and Cys42 | |||||
| ↓NKA activity (Tulloch et al., 2011; Hilgemann et al., 2013) | |||||
| FXYD2 | γ Subunit | Restricted to kidney and pancreas | ↓Sodium affinity (Béguin et al., 1997; Arystarkhova et al., 1999, 2002a; Therien et al., 1999; Meyer et al., 2020) | Unknown | Unknown |
| FXYD3 | Mammary tumor (Mat-8) | Restricted to tissues rich in smooth muscle, skin, and salivary gland | Mixed results (Crambert et al., 2005; Bibert et al., 2006; Wujak et al., 2016) | Glutathionylation at Cys40 and Cys42 | Unknown |
| ↑NKA activity (Bibert et al., 2006) | |||||
| FXYD4 | CHIF | Restricted to kidney, inducible in colon with corticosteroid | ↑Sodium affinity and Vmax (Béguin et al., 2001; Meyer et al., 2020) | Unknown | CHIF increases sodium reabsorption in the colon and kidneys during sodium deprivation (Aizman et al., 2002) |
| FXYD5 | Related ion channel, dysadherin | Expressed in multiple tissue types and almost completely absent in brain tissue | ↑Sodium affinity and Vmax, ↓potassium affinity (Lubarski et al., 2007; Mathias et al., 2008) | Palmitoylation and glycosylation | Dysadherin increases cancer invasiveness (Ino et al., 2002) |
| FXYD6 | Phosphohippolin | Expressed in multiple tissue types | ↓Sodium affinity (Delprat et al., 2007b; Meyer et al., 2020) | Unknown | Unknown |
| FXYD7 | N/A | Brain | ↓Potassium affinity, ↑sodium affinity (Béguin et al., 2002; Meyer et al., 2020) | Glycosylation at Thr5 and Thr9 | Unknown |
| ↑FXYD7 stabilization and translocation to the plasma membrane (Moshitzky et al., 2012) |
| FXYD protein . | Other name . | Expression pattern . | Effects on NKA . | Posttranslational modifications and effects on NKA . | Physiological/pathological role . |
|---|---|---|---|---|---|
| FXYD1 | PLM | Expresses in multiple tissue types | ↓Sodium affinity (Crambert et al., 2002; Despa et al., 2005; Bossuyt et al., 2009; Meyer et al., 2020) | Phosphorylation at Ser63, Ser68, and Ser69 | PLM is required for the sympathetic simulation of the NKA in cardiomyocytes (Despa et al., 2005) |
| ↑NKA activity (Fuller et al., 2009; Despa et al., 2005), glutathionylation at Cys42 ↑NKA activity (Bibert et al., 2011), palmitoylation at Cys40 and Cys42 | |||||
| ↓NKA activity (Tulloch et al., 2011; Hilgemann et al., 2013) | |||||
| FXYD2 | γ Subunit | Restricted to kidney and pancreas | ↓Sodium affinity (Béguin et al., 1997; Arystarkhova et al., 1999, 2002a; Therien et al., 1999; Meyer et al., 2020) | Unknown | Unknown |
| FXYD3 | Mammary tumor (Mat-8) | Restricted to tissues rich in smooth muscle, skin, and salivary gland | Mixed results (Crambert et al., 2005; Bibert et al., 2006; Wujak et al., 2016) | Glutathionylation at Cys40 and Cys42 | Unknown |
| ↑NKA activity (Bibert et al., 2006) | |||||
| FXYD4 | CHIF | Restricted to kidney, inducible in colon with corticosteroid | ↑Sodium affinity and Vmax (Béguin et al., 2001; Meyer et al., 2020) | Unknown | CHIF increases sodium reabsorption in the colon and kidneys during sodium deprivation (Aizman et al., 2002) |
| FXYD5 | Related ion channel, dysadherin | Expressed in multiple tissue types and almost completely absent in brain tissue | ↑Sodium affinity and Vmax, ↓potassium affinity (Lubarski et al., 2007; Mathias et al., 2008) | Palmitoylation and glycosylation | Dysadherin increases cancer invasiveness (Ino et al., 2002) |
| FXYD6 | Phosphohippolin | Expressed in multiple tissue types | ↓Sodium affinity (Delprat et al., 2007b; Meyer et al., 2020) | Unknown | Unknown |
| FXYD7 | N/A | Brain | ↓Potassium affinity, ↑sodium affinity (Béguin et al., 2002; Meyer et al., 2020) | Glycosylation at Thr5 and Thr9 | Unknown |
| ↑FXYD7 stabilization and translocation to the plasma membrane (Moshitzky et al., 2012) |
Expression patterns were obtained from the GTEx Portal. N/A, not applicable.