Table 3. Pore-lining residues in hCFTR... | Rockefeller University Press

Table 3.

Pore-lining residues in hCFTR predicted by experiment

Region	Residue numbers	Aggregate Grantham score^a
TM1	92, 95, 98, 102, 106,107, 109	111
ICL1	186, 188, 189, 190,	32
TM3	191, 192, 193, 194, 195, 196, 197, 199, 200,203, 205, 207, 211, 213, 215	532
ICL2	241, 243, 244, 248, 252,299, 303,	142
TM5	306,307, 310, 311, 326	209
TM6	331, 333, 334, 335, 336, 337,338, 339, 340, 341, 342, 344, 345, 348, 349, 352, 353, 355,356, 360, 367, 370	1,389
TM8	913, 914, 917	327
ICL3	986, 988, 989, 990	0
TM9	993,1000, 1003, 1008, 1009, 1010	361
ICL4	1030, 1041, 1048	0
TM11	1112, 1115, 1118	58
TM12	1127, 1129, 1131, 1132, 1134, 1135, 1137, 1138, 1139, 1140, 1141, 1142, 1144, 1145, 1147,1148, 1150, 1152, 1156	561

Region	Residue numbers	Aggregate Grantham score^a
TM1	92, 95, 98, 102, 106,107, 109	111
ICL1	186, 188, 189, 190,	32
TM3	191, 192, 193, 194, 195, 196, 197, 199, 200,203, 205, 207, 211, 213, 215	532
ICL2	241, 243, 244, 248, 252,299, 303,	142
TM5	306,307, 310, 311, 326	209
TM6	331, 333, 334, 335, 336, 337,338, 339, 340, 341, 342, 344, 345, 348, 349, 352, 353, 355,356, 360, 367, 370	1,389
TM8	913, 914, 917	327
ICL3	986, 988, 989, 990	0
TM9	993,1000, 1003, 1008, 1009, 1010	361
ICL4	1030, 1041, 1048	0
TM11	1112, 1115, 1118	58
TM12	1127, 1129, 1131, 1132, 1134, 1135, 1137, 1138, 1139, 1140, 1141, 1142, 1144, 1145, 1147,1148, 1150, 1152, 1156	561

Italics = identical; underlined = divergent; unformatted = similar.

A higher Grantham score indicates less conservation.