| . | Lp-CFTR . | hCFTR . |
|---|---|---|
| Functional domain: channel behavior . | ||
| Open channel stability (open burst duration) | Low | High |
| Frequency of subconductance states | High | Low |
| Single-channel open conductance | Low | High |
| Shape of I-V relationship | Rectified | Linear |
| Sensitivity to (affinity for) ATP for channel opening | Very low | High |
| Functional domain: regulation by phosphorylation | ||
| Rate of activation by PKA-mediated phosphorylation | Low | High |
| Number of predicted PKA sites in the R domain | 4 | 8 |
| Functional domain: pharmacological modulation | ||
| Effect of VX-770/ivacaftor (inhibition versus potentiation) | Small inhibition | Potentiation |
| Inhibition by CFTRinh172 | Low | High |
| Sensitivity to pore block by GlyH-101 | None | High |
| Sensitivity to pore block by NPPB | Low | High |
| Sensitivity to pore block by glibenclamide | Equal | Equal |
| . | Lp-CFTR . | hCFTR . |
|---|---|---|
| Functional domain: channel behavior . | ||
| Open channel stability (open burst duration) | Low | High |
| Frequency of subconductance states | High | Low |
| Single-channel open conductance | Low | High |
| Shape of I-V relationship | Rectified | Linear |
| Sensitivity to (affinity for) ATP for channel opening | Very low | High |
| Functional domain: regulation by phosphorylation | ||
| Rate of activation by PKA-mediated phosphorylation | Low | High |
| Number of predicted PKA sites in the R domain | 4 | 8 |
| Functional domain: pharmacological modulation | ||
| Effect of VX-770/ivacaftor (inhibition versus potentiation) | Small inhibition | Potentiation |
| Inhibition by CFTRinh172 | Low | High |
| Sensitivity to pore block by GlyH-101 | None | High |
| Sensitivity to pore block by NPPB | Low | High |
| Sensitivity to pore block by glibenclamide | Equal | Equal |
NPPB, 5-nitro-2-(3-phenyl-propylamino) benzoic acid. Related to Cui et al., 2019a.